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Pulsed Light Stimulation Increases Boundary Preference and Periodicity of Episodic Motor Activity in Drosophila melanogaster

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  • Shuang Qiu
  • Chengfeng Xiao
  • R Meldrum Robertson

Abstract

There is considerable interest in the therapeutic benefits of long-term sensory stimulation for improving cognitive abilities and motor performance of stroke patients. The rationale is that such stimulation would activate mechanisms of neural plasticity to promote enhanced coordination and associated circuit functions. Experimental approaches to characterize such mechanisms are needed. Drosophila melanogaster is one of the most attractive model organisms to investigate neural mechanisms responsible for stimulation-induced behaviors with its powerful accessibility to genetic analysis. In this study, the effect of chronic sensory stimulation (pulsed light stimulation) on motor activity in w1118 flies was investigated. Flies were exposed to a chronic pulsed light stimulation protocol prior to testing their performance in a standard locomotion assay. Flies responded to pulsed light stimulation with increased boundary preference and travel distance in a circular arena. In addition, pulsed light stimulation increased the power of extracellular electrical activity, leading to the enhancement of periodic electrical activity which was associated with a centrally-generated motor pattern (struggling behavior). In contrast, such periodic events were largely missing in w1118 flies without pulsed light treatment. These data suggest that the sensory stimulation induced a response in motor activity associated with the modifications of electrical activity in the central nervous system (CNS). Finally, without pulsed light treatment, the wild-type genetic background was associated with the occurrence of the periodic activity in wild-type Canton S (CS) flies, and w+ modulated the consistency of periodicity. We conclude that pulsed light stimulation modifies behavioral and electrophysiological activities in w1118 flies. These data provide a foundation for future research on the genetic mechanisms of neural plasticity underlying such behavioral modification.

Suggested Citation

  • Shuang Qiu & Chengfeng Xiao & R Meldrum Robertson, 2016. "Pulsed Light Stimulation Increases Boundary Preference and Periodicity of Episodic Motor Activity in Drosophila melanogaster," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-16, September.
    • Handle: RePEc:plo:pone00:0163976
    DOI: 10.1371/journal.pone.0163976
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    References listed on IDEAS

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    1. Chengfeng Xiao & R Meldrum Robertson, 2015. "Locomotion Induced by Spatial Restriction in Adult Drosophila," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-19, September.
    2. Joan S. Steffan & Laszlo Bodai & Judit Pallos & Marnix Poelman & Alexander McCampbell & Barbara L. Apostol & Alexsey Kazantsev & Emily Schmidt & Ya-Zhen Zhu & Marilee Greenwald & Riki Kurokawa & David, 2001. "Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila," Nature, Nature, vol. 413(6857), pages 739-743, October.
    3. Maximiliano L. Suster & Michael Bate, 2002. "Embryonic assembly of a central pattern generator without sensory input," Nature, Nature, vol. 416(6877), pages 174-178, March.
    4. Pavan Ramdya & Pawel Lichocki & Steeve Cruchet & Lukas Frisch & Winnie Tse & Dario Floreano & Richard Benton, 2015. "Mechanosensory interactions drive collective behaviour in Drosophila," Nature, Nature, vol. 519(7542), pages 233-236, March.
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