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Embryonic assembly of a central pattern generator without sensory input

Author

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  • Maximiliano L. Suster

    (University of Cambridge
    University of Toronto at Mississauga)

  • Michael Bate

    (University of Cambridge)

Abstract

Locomotion depends on the integration of sensory information with the activity of central circuitry, which generates patterned discharges in motor nerves to appropriate muscles1,2. Isolated central networks generate fictive locomotor rhythms (recorded in the absence of movement), indicating that the fundamental pattern of motor output depends on the intrinsic connectivity and electrical properties of these central circuits3,4. Sensory inputs are required to modify the pattern of motor activity in response to the actual circumstances of real movement. A central issue for our understanding of how locomotor circuits are specified and assembled is the extent to which sensory inputs are required as such systems develop5. Here we describe the effects of eliminating sensory function and structure on the development of the peristaltic motor pattern of Drosophila embryos and larvae. We infer that the circuitry for peristaltic crawling develops in the complete absence of sensory input; however, the integration of this circuitry into actual patterns of locomotion requires additional information from the sensory system. In the absence of sensory inputs, the polarity of movement is deranged, and backward peristaltic waves predominate at the expense of forward peristalsis.

Suggested Citation

  • Maximiliano L. Suster & Michael Bate, 2002. "Embryonic assembly of a central pattern generator without sensory input," Nature, Nature, vol. 416(6877), pages 174-178, March.
  • Handle: RePEc:nat:nature:v:416:y:2002:i:6877:d:10.1038_416174a
    DOI: 10.1038/416174a
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    Cited by:

    1. William H Barnett & Gennady S Cymbalyuk, 2014. "A Codimension-2 Bifurcation Controlling Endogenous Bursting Activity and Pulse-Triggered Responses of a Neuron Model," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-14, January.
    2. Shuang Qiu & Chengfeng Xiao & R Meldrum Robertson, 2016. "Pulsed Light Stimulation Increases Boundary Preference and Periodicity of Episodic Motor Activity in Drosophila melanogaster," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-16, September.
    3. Katerina Karkali & Samuel W. Vernon & Richard A. Baines & George Panayotou & Enrique Martín-Blanco, 2023. "Puckered and JNK signaling in pioneer neurons coordinates the motor activity of the Drosophila embryo," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Joshua M Mueller & Primoz Ravbar & Julie H Simpson & Jean M Carlson, 2019. "Drosophila melanogaster grooming possesses syntax with distinct rules at different temporal scales," PLOS Computational Biology, Public Library of Science, vol. 15(6), pages 1-25, June.

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