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Alcohol Intake and Serum Glucose Levels from the Perspective of a Mendelian Randomization Design: The KCPS-II Biobank

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  • Yon Ho Jee
  • Sun Ju Lee
  • Keum Ji Jung
  • Sun Ha Jee

Abstract

Background: Previous studies have suggested that alcohol intake is associated with increased fasting serum glucose (FSG), but the nature of the relationship remains unknown. We used Mendelian randomization analysis to assess the causal effect of alcohol intake on FSG in a middle-aged Korean population. Methods: Clinical data including FSG and alcohol intake were collected from 156,386 Koreans aged 20 years or older who took part in the Korean Cancer Prevention Study-II (KCPS-II) Biobank Cohort. The single nucleotide polymorphism rs671 in ALDH2 was genotyped among 2,993 men and 1,374 women in 2016. This was a randomly selected subcohort of KCPS-II Biobank participants. Results: Alcohol consumption was positively associated with FSG level in men, but not in women. The rs671 major G allele was associated with increased alcohol intake (F-statistic = 302.62) and an increase in FSG in men. Using Mendelian randomization analysis, alcohol intake increased FSG by 1.78 mg/dL per alcohol unit (10 g ethanol) per day (95% CI: 0.97–2.59) in men. The associations became stronger when we excluded heavy drinkers and the elderly. However, in women, no significant association between rs671 and alcohol or serum glucose was found. Conclusion: Using Mendelian randomization analysis, we suggest a causal relationship between alcohol intake and FSG among Korean men. Moreover, we found that the ALDH2 variant rs671 was not associated with FSG among Korean women.

Suggested Citation

  • Yon Ho Jee & Sun Ju Lee & Keum Ji Jung & Sun Ha Jee, 2016. "Alcohol Intake and Serum Glucose Levels from the Perspective of a Mendelian Randomization Design: The KCPS-II Biobank," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-9, September.
    • Handle: RePEc:plo:pone00:0162930
    DOI: 10.1371/journal.pone.0162930
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    References listed on IDEAS

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    1. Lin Xu & Chao Qiang Jiang & Kar Keung Cheng & Shiu Lun Ryan Au Yeung & Wei Sen Zhang & Tai Hing Lam & Catherine Mary Schooling, 2015. "Alcohol Use and Gamma-Glutamyltransferase Using a Mendelian Randomization Design in the Guangzhou Biobank Cohort Study," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-10, September.
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    Cited by:

    1. Stefano Castriota & Paolo Frumento & Francesco Suppressa, 2023. "How much is too much? A methodological investigation of the literature on alcohol consumption," Discussion Papers 2023/297, Dipartimento di Economia e Management (DEM), University of Pisa, Pisa, Italy.
    2. Stefano Castriota & Paolo Frumento & Francesco Suppressa, 2023. "How Much Is Too Much? A Methodological Investigation Of The Literature On Alcohol Consumption," CEIS Research Paper 560, Tor Vergata University, CEIS, revised 06 Jul 2023.

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