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The Prognostic and Clinicopathological Roles of Sirtuin-3 in Various Cancers

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  • Fei-Yuan Yu
  • Qian Xu
  • Dan-Dan Wu
  • Andy T Y Lau
  • Yan-Ming Xu

Abstract

Sirtuin-3 (SIRT3) is a major mitochondrial NAD(+)-dependent deacetylase and plays a key role in the progression and development of human cancers. Although the prognostic and clinicopathological features of SIRT3 expression in various cancers have been investigated by different research groups, however, inconsistent and opposing results can be observed. In this study, we therefore performed a meta-analysis to evaluate the significance of SIRT3 expression in various cancers. Systematic literature searching was performed in PubMed, Embase, China National Knowledge Infrastructure, and Wanfang Data up to November 2015. Total effect analyses and subgroup analyses were performed to evaluate the relationship between SIRT3 expression and overall survival, cancer/non-cancer tissues, lymph node metastasis, pathological differentiation, tumor node metastasis (TNM) stage, tumor size, and gender, in various cancer patients. Hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to clarify the risk or hazard association. A total of 14 studies comprising 2165 cancer patients were included to assess the association between SIRT3 immunohistochemical expression and overall survival or clinicopathological characteristics. SIRT3 expression was significantly associated with overall survival in gastric cancer (HR = 0.62, 95% CI = 0.43–0.89, P = 0.009) and hepatocellular carcinoma patients (HR = 0.56, 95% CI = 0.42–0.74, P

Suggested Citation

  • Fei-Yuan Yu & Qian Xu & Dan-Dan Wu & Andy T Y Lau & Yan-Ming Xu, 2016. "The Prognostic and Clinicopathological Roles of Sirtuin-3 in Various Cancers," PLOS ONE, Public Library of Science, vol. 11(8), pages 1-12, August.
    • Handle: RePEc:plo:pone00:0159801
    DOI: 10.1371/journal.pone.0159801
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    References listed on IDEAS

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    1. Toren Finkel & Chu-Xia Deng & Raul Mostoslavsky, 2009. "Recent progress in the biology and physiology of sirtuins," Nature, Nature, vol. 460(7255), pages 587-591, July.
    2. Chris Zhiyi Zhang & Lili Liu & Muyan Cai & Yinghua Pan & Jia Fu & Yun Cao & Jingping Yun, 2012. "Low SIRT3 Expression Correlates with Poor Differentiation and Unfavorable Prognosis in Primary Hepatocellular Carcinoma," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-11, December.
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