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Decrease of Fibulin-3 in Hepatocellular Carcinoma Indicates Poor Prognosis

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  • Rongzhen Luo
  • Meifang Zhang
  • Lili Liu
  • Shixun Lu
  • Chris Zhiyi Zhang
  • Jingping Yun

Abstract

Fibulin-3, originally identified in senescent and Werner syndrome fibroblasts, has been implicated in cell morphology, growth, adhesion and motility. Fibulin-3 exhibits both antitumor and oncogenic activities towards human cancers; however, the role of Fibulin-3 in hepatocellular carcinoma (HCC) remains elusive. In this study, we showed that both the mRNA and protein levels of Fibulin-3 were remarkably downregulated in HCC cell lines and fresh tissues. Immunohistochemical data revealed that Fibulin-3 was decreased in tumorous tissues in 67.1% (171/255) of cases compared to the corresponding adjacent nontumorous tissues. The results of statistical analysis indicated that low Fibulin-3 expression, defined by the receiver operating characteristic curve (ROC), was significantly associated with tumor differentiation (P = 0.008), clinical stage (P = 0.014) and serum AFP levels (P

Suggested Citation

  • Rongzhen Luo & Meifang Zhang & Lili Liu & Shixun Lu & Chris Zhiyi Zhang & Jingping Yun, 2013. "Decrease of Fibulin-3 in Hepatocellular Carcinoma Indicates Poor Prognosis," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-11, August.
    • Handle: RePEc:plo:pone00:0070511
    DOI: 10.1371/journal.pone.0070511
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    References listed on IDEAS

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    1. Chris Zhiyi Zhang & Lili Liu & Muyan Cai & Yinghua Pan & Jia Fu & Yun Cao & Jingping Yun, 2012. "Low SIRT3 Expression Correlates with Poor Differentiation and Unfavorable Prognosis in Primary Hepatocellular Carcinoma," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-11, December.
    2. Lili Liu & Chris Zhiyi Zhang & Muyan Cai & Jia Fu & George Gong Chen & Jingping Yun, 2012. "Downregulation of Polo-Like Kinase 4 in Hepatocellular Carcinoma Associates with Poor Prognosis," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-8, July.
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