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A Study of the Variation in the Salivary Peptide Profiles of Young Healthy Adults Acquired Using MALDI-TOF MS

Author

Listed:
  • Andrei Prodan
  • Henk Brand
  • Sultan Imangaliyev
  • Evgeni Tsivtsivadze
  • Fridus van der Weijden
  • Ad de Jong
  • Armand Paauw
  • Wim Crielaard
  • Bart Keijser
  • Enno Veerman

Abstract

A cross-sectional observational study was conducted to evaluate the inter-individual variation in the MALDI-TOF MS peptide profiles of unstimulated whole saliva in a population of 268 systemically healthy adults aged 18–30 yr (150 males and 118 females) with no apparent caries lesions or periodontal disease. Using Spectral Clustering, four subgroups of individuals were identified within the study population. These subgroups were delimited by the pattern of variation in 9 peaks detected in the 2–15 kDa m/z range. An Unsupervised Feature Selection algorithm showed that P-C peptide, a 44 residue-long salivary acidic proline-rich protein, and three of its fragments (Fr. 1–25, Fr. 15–35 and Fr. 15–44) play a central role in delimiting the subgroups. Significant differences were found in the salivary biochemistry of the subgroups with regard to lysozyme and chitinase, two enzymes that are part of the salivary innate defense system (p

Suggested Citation

  • Andrei Prodan & Henk Brand & Sultan Imangaliyev & Evgeni Tsivtsivadze & Fridus van der Weijden & Ad de Jong & Armand Paauw & Wim Crielaard & Bart Keijser & Enno Veerman, 2016. "A Study of the Variation in the Salivary Peptide Profiles of Young Healthy Adults Acquired Using MALDI-TOF MS," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-15, June.
    • Handle: RePEc:plo:pone00:0156707
    DOI: 10.1371/journal.pone.0156707
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    References listed on IDEAS

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    1. ter Braak, Cajo J.F. & Kourmpetis, Yiannis & Kiers, Henk A.L. & Bink, Marco C.A.M., 2009. "Approximating a similarity matrix by a latent class model: A reappraisal of additive fuzzy clustering," Computational Statistics & Data Analysis, Elsevier, vol. 53(8), pages 3183-3193, June.
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