Antibioprophylaxis in Prevention of Endophthalmitis in Intravitreal Injection: A Systematic Review and Meta-Analysis
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DOI: 10.1371/journal.pone.0156431
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Keywords
" antibiotic*" ; " endophthalmitis" and “intravitreal injection*”. to be included; studies needed to specify number of participants and number of endophthalmitis within each group (with and without antibiotics). we conducted meta-analysis on the prevalence of clinical endophthalmitis including both culture-proven and culture negative samples. nine studies were included. a total of 88 incidences of endophthalmitis were reported from 174; 159 injections (0.051% i.e.; one incidence of endophthalmitis for 1979 injections). specifically; 59 incidences of endophthalmitis were reported from 113; 530 injections in the group with antibiotics (0.052% or one incidence of endophthalmitis for 1924 injections) and 29 incidences of endophthalmitis from 60; 633 injections in the group without antibiotics (0.048% or one endophthalmitis for 2091 injections). our meta-analysis did not report a significant difference in the prevalence of clinical endophthalimitis between the two groups with and without topical antibiotics: the odds ratio of clinical endophthalimitis was 0.804 (ci95% 0.384–1.682; p = 0.56) for the antibiotic group compared with the group without antibiotics. in conclusion; we performed the first large meta-analysis demonstrating that antibioprophylaxis is not required in intravitreal injections. strict rules of asepsis remain the only evidence-based prophylaxis of endophthalmitis. the results support initiatives to reduce the global threat of resistance to antibiotics.;All these keywords.
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