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Enhancement of Chemotactic Cell Aggregation by Haptotactic Cell-To-Cell Interaction

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  • Tae-goo Kwon
  • Taeseok Daniel Yang
  • Kyoung J Lee

Abstract

The crawling of biological cell is a complex phenomenon involving various biochemical and mechanical processes. Some of these processes are intrinsic to individual cells, while others pertain to cell-to-cell interactions and to their responses to extrinsically imposed cues. Here, we report an interesting aggregation dynamics of mathematical model cells, when they perform chemotaxis in response to an externally imposed global chemical gradient while they influence each other through a haptotaxis-mediated social interaction, which confers intriguing trail patterns. In the absence of the cell-to-cell interaction, the equilibrium population density profile fits well to that of a simple Keller-Segal population dynamic model, in which a chemotactic current density J → c h e m o ∼ ∇ p competes with a normal diffusive current density J → d i f f ∼ ∇ ρ, where p and ρ refer to the concentration of chemoattractant and population density, respectively. We find that the cell-to-cell interaction confers a far more compact aggregation resulting in a much higher peak equilibrium cell density. The mathematical model system is applicable to many biological systems such as swarming microglia and neutrophils or accumulating ants towards a localized food source.

Suggested Citation

  • Tae-goo Kwon & Taeseok Daniel Yang & Kyoung J Lee, 2016. "Enhancement of Chemotactic Cell Aggregation by Haptotactic Cell-To-Cell Interaction," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-14, April.
  • Handle: RePEc:plo:pone00:0154717
    DOI: 10.1371/journal.pone.0154717
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    References listed on IDEAS

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    1. Taeseok Daniel Yang & Jin-Sung Park & Youngwoon Choi & Wonshik Choi & Tae-Wook Ko & Kyoung J Lee, 2011. "Zigzag Turning Preference of Freely Crawling Cells," PLOS ONE, Public Library of Science, vol. 6(6), pages 1-9, June.
    2. Tim Lämmermann & Philippe V. Afonso & Bastian R. Angermann & Ji Ming Wang & Wolfgang Kastenmüller & Carole A. Parent & Ronald N. Germain, 2013. "Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo," Nature, Nature, vol. 498(7454), pages 371-375, June.
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