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Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo

Author

Listed:
  • Tim Lämmermann

    (Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Philippe V. Afonso

    (Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health)

  • Bastian R. Angermann

    (Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Ji Ming Wang

    (Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health)

  • Wolfgang Kastenmüller

    (Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
    Institutes of Molecular Medicine and Experimental Immunology (IMMEI), University of Bonn, 53105 Bonn, Germany)

  • Carole A. Parent

    (Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health)

  • Ronald N. Germain

    (Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

Abstract

Two-photon intravital imaging is used here to define the regulation of interstitial neutrophil migration at local sites of cell death upon sterile tissue injury and infection; leukotriene B4 (LTB4) is shown to act between neutrophils as a signal relay molecule that acts to enhance the radius of neutrophil recruitment within the inflamed interstitium, and also to control, in concert with integrin receptors, dense neutrophil clustering for tight wound seal formation.

Suggested Citation

  • Tim Lämmermann & Philippe V. Afonso & Bastian R. Angermann & Ji Ming Wang & Wolfgang Kastenmüller & Carole A. Parent & Ronald N. Germain, 2013. "Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo," Nature, Nature, vol. 498(7454), pages 371-375, June.
    • Handle: RePEc:nat:nature:v:498:y:2013:i:7454:d:10.1038_nature12175
    DOI: 10.1038/nature12175
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    Cited by:

    1. Tae-goo Kwon & Taeseok Daniel Yang & Kyoung J Lee, 2016. "Enhancement of Chemotactic Cell Aggregation by Haptotactic Cell-To-Cell Interaction," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-14, April.
    2. Régis Joulia & Idaira María Guerrero-Fonseca & Tamara Girbl & Jonathon A. Coates & Monja Stein & Laura Vázquez-Martínez & Eleanor Lynam & James Whiteford & Michael Schnoor & David Voehringer & Axel Ro, 2022. "Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Yanbo Kou & Shenghan Zhang & Junru Chen & Yusi Shen & Zhiwei Zhang & Haohan Huang & Yulu Ma & Yaoyao Xiang & Longxiang Liao & Junyang Zhou & Wanpeng Cheng & Yuan Zhou & Huan Yang & Zhuanzhuan Liu & Ya, 2024. "A mouse protozoan boosts antigen-specific mucosal IgA responses in a specific lipid metabolism- and signaling-dependent manner," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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