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A HuGE Review and Meta-Analyses of Genetic Associations in New Onset Diabetes after Kidney Transplantation

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  • Katherine Angela Benson
  • Alexander Peter Maxwell
  • Amy Jayne McKnight

Abstract

Purpose: New onset diabetes after transplantation (NODAT) is a serious complication following solid organ transplantation. There is a genetic contribution to NODAT and we have conducted comprehensive meta-analysis of available genetic data in kidney transplant populations. Methods: Relevant articles investigating the association between genetic markers and NODAT were identified by searching PubMed, Web of Science and Google Scholar. SNPs described in a minimum of three studies were included for analysis using a random effects model. The association between identified variants and NODAT was calculated at the per-study level to generate overall significance values and effect sizes. Results: Searching the literature returned 4,147 citations. Within the 36 eligible articles identified, 18 genetic variants from 12 genes were considered for analysis. Of these, three were significantly associated with NODAT by meta-analysis at the 5% level of significance; CDKAL1 rs10946398 p = 0.006 OR = 1.43, 95% CI = 1.11–1.85 (n = 696 individuals), KCNQ1 rs2237892 p = 0.007 OR = 1.43, 95% CI = 1.10–1.86 (n = 1,270 individuals), and TCF7L2 rs7903146 p = 0.01 OR = 1.41, 95% CI = 1.07–1.85 (n = 2,967 individuals). Conclusion: Evaluating cumulative evidence for SNPs associated with NODAT in kidney transplant recipients has revealed three SNPs associated with NODAT. An adequately powered, dense genome-wide association study will provide more information using a carefully defined NODAT phenotype.

Suggested Citation

  • Katherine Angela Benson & Alexander Peter Maxwell & Amy Jayne McKnight, 2016. "A HuGE Review and Meta-Analyses of Genetic Associations in New Onset Diabetes after Kidney Transplantation," PLOS ONE, Public Library of Science, vol. 11(1), pages 1-13, January.
    • Handle: RePEc:plo:pone00:0147323
    DOI: 10.1371/journal.pone.0147323
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    References listed on IDEAS

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    1. Deng Ao & Hai-jun Wang & Li-fang Wang & Jie-yun Song & Hui-xia Yang & Yan Wang, 2015. "The rs2237892 Polymorphism in KCNQ1 Influences Gestational Diabetes Mellitus and Glucose Levels: A Case-Control Study and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-11, June.
    2. Kim, Jaehoon & Kim, Sangsin, 2015. "2012년 국회법 개정의 효과 연구 [A Study on the Effect of the 2012 National Assembly Act Amendment]," KDI Research Monographs, Korea Development Institute (KDI), volume 127, number v:2015-03(k):y:2015:p:1-1.
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