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The Association between Insomnia and Insomnia Treatment Side Effects on Health Status, Work Productivity, and Healthcare Resource Use

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  • Marco DiBonaventura
  • Lance Richard
  • Maya Kumar
  • Anna Forsythe
  • Natalia M Flores
  • Margaret Moline

Abstract

The aims of this study were (1) to compare health outcomes (i.e., health-related quality of life [HRQoL], productivity at work, and healthcare resource use visits) between those with insomnia and non-insomnia controls, (2) to compare health outcomes between those treated for insomnia and non-insomnia controls, and (3) to assess the prevalence of side effects of insomnia medications and their relationship with health outcomes. Data from the 2013 US (N = 75,000) and 5EU (N = 62,000) National Health and Wellness Survey (NHWS) were used. The NHWS is a patient-reported survey administered to a demographically representative sample of adults. Those who met DSM-V criteria for insomnia and, separately, those treated for insomnia were compared with equivalently sized control groups who were identified using a propensity score matching method. Outcomes included HRQoL (Short Form 36v2), productivity at work (Work Productivity and Activity Impairment—General Health questionnaire), and healthcare resource use visits in the past 6 months and were analyzed using one-way ANOVAs. Among those with treated insomnia, those with and without side effects were compared on health outcomes using general linear models controlling for confounding variables. Patients with insomnia (n = 4147) and treated insomnia (n = 2860) in the 5EU reported significantly worse HRQoL than controls (health utilities: 0.60 vs. 0.74; 0.60 vs. 0.74, respectively), greater overall work impairment (38.74% vs. 14.86%; 39.50% vs. 15.66%), and more physician visits in the past 6 months (9.10 vs. 4.08; 9.58 vs. 4.11). Similar findings were observed in the US. Among those treated for insomnia, 13.56% and 24.55% in the US and 5EU, respectively, were non-adherent due to side effects. In the US, non-adherence was associated with significantly worse HRQoL (health utilities: 0.60 vs. 0.64, p

Suggested Citation

  • Marco DiBonaventura & Lance Richard & Maya Kumar & Anna Forsythe & Natalia M Flores & Margaret Moline, 2015. "The Association between Insomnia and Insomnia Treatment Side Effects on Health Status, Work Productivity, and Healthcare Resource Use," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-14, October.
    • Handle: RePEc:plo:pone00:0137117
    DOI: 10.1371/journal.pone.0137117
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    References listed on IDEAS

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    1. John Brazier & Jennifer Roberts & Aki Tsuchiya & Jan Busschbach, 2004. "A comparison of the EQ‐5D and SF‐6D across seven patient groups," Health Economics, John Wiley & Sons, Ltd., vol. 13(9), pages 873-884, September.
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    1. Marco Hafner & Erez Yerushalmi & Fredrik L. Andersson & Teodor Burtea, 2023. "Partially different? The importance of general equilibrium in health economic evaluations: An application to nocturia," Health Economics, John Wiley & Sons, Ltd., vol. 32(3), pages 654-674, March.
    2. Kuniyoshi Toyoshima & Takeshi Inoue & Akiyoshi Shimura & Yoshihiro Uchida & Jiro Masuya & Yota Fujimura & Shinji Higashi & Ichiro Kusumi, 2021. "Mediating Roles of Cognitive Complaints on Relationships between Insomnia, State Anxiety, and Presenteeism in Japanese Adult Workers," IJERPH, MDPI, vol. 18(9), pages 1-12, April.
    3. Thomas Grochtdreis & Hans-Helmut König & Judith Dams, 2021. "Health-Related Quality of Life of Persons with Direct, Indirect and No Migration Background in Germany: A Cross-Sectional Study Based on the German Socio-Economic Panel (SOEP)," IJERPH, MDPI, vol. 18(7), pages 1-12, April.
    4. Juan Vega-Escaño & Ana María Porcel-Gálvez & Rocío de Diego-Cordero & José Manuel Romero-Sánchez & Manuel Romero-Saldaña & Sergio Barrientos-Trigo, 2020. "Insomnia Interventions in the Workplace: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 17(17), pages 1-18, September.

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