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Prognostic Value of Circulating Tumor Cells in Ovarian Cancer: A Meta-Analysis

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  • Yunlan Zhou
  • Bingxian Bian
  • Xiangliang Yuan
  • Guohua Xie
  • Yanhui Ma
  • Lisong Shen

Abstract

Background: The prognostic value of circulating tumor cells (CTCs) in ovarian cancer has been investigated in previous studies, but the results are controversial. Therefore we performed a meta-analysis to systematically review these data and evaluate the value of CTCs in ovarian cancer. Materials and Methods: A literary search for relevant studies was performed on Embase, Medline and Web of Science databases. Then pooled hazard ratios (HRs) for survival with 95% confidence intervals (CIs), subgroup analyses, sensitivity analyses, meta-regression analyses and publication bias were conducted. Results: This meta-analysis is based on 11 publications and comprises a total of 1129 patients. The prognostic value of the CTC status was significant in overall survival (OS) (HR, 1.61;95% CI,1.22–2.13) and progression-free survival (PFS)/disease-free survival (DFS) (HR, 1.44; 95%CI, 1.18–1.75). Furthermore, subgroup analysis revealed that the value of CTC status in OS was significant in "RT-PCR" subgroup (HR, 2.02; 95% CI, 1.34–3.03), whereas it was not significant in "CellSearch" subgroup (HR, 1.15; 95% CI 0.45–2.92) and "other ICC" subgroup (HR, 1.09; 95% CI 0.62–1.90). The presence of CTC was also associated with an increased CA-125 (OR, 4.07; 95%CI, 1.87–8.85). Conclusion: Our study demonstrates that CTC status is associated with OS and PFS/DFS in ovarian cancer.

Suggested Citation

  • Yunlan Zhou & Bingxian Bian & Xiangliang Yuan & Guohua Xie & Yanhui Ma & Lisong Shen, 2015. "Prognostic Value of Circulating Tumor Cells in Ovarian Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-14, June.
    • Handle: RePEc:plo:pone00:0130873
    DOI: 10.1371/journal.pone.0130873
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    References listed on IDEAS

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    1. Shuyi Wang & Gang Zheng & Boran Cheng & Fangfang Chen & Zhenmeng Wang & Yuanyuan Chen & You Wang & Bin Xiong, 2014. "Circulating Tumor Cells (CTCs) Detected by RT-PCR and Its Prognostic Role in Gastric Cancer: A Meta-Analysis of Published Literature," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-7, June.
    2. Jianwei Huang & Ke Wang & Jianjun Xu & Jian Huang & Tao Zhang, 2013. "Prognostic Significance of Circulating Tumor Cells in Non-Small-Cell Lung Cancer Patients: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-8, November.
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