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Circulating Tumor Cells (CTCs) Detected by RT-PCR and Its Prognostic Role in Gastric Cancer: A Meta-Analysis of Published Literature

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  • Shuyi Wang
  • Gang Zheng
  • Boran Cheng
  • Fangfang Chen
  • Zhenmeng Wang
  • Yuanyuan Chen
  • You Wang
  • Bin Xiong

Abstract

Objective: The prognostic significance of circulating tumor cells (CTCs) is controversial in gastric cancer (GC). We performed a meta-analysis of available studies to assess its prognostic value detected by RT-PCR for patients diagnosed with GC. Methods: EMBase, PubMed, Ovid, Web of Science, Cochrane library and Google Scholar database search was conducted on all studies reporting the outcomes of interest. The studies were set up according to the inclusion/exclusion criteria. Meta-analysis was performed by using a random-effects model; hazard ratio (HR), risk ratio (RR) and their 95% confidence intervals (95% CIs) were set as effect measures. The information about trial design, results from the data was independently extracted. Heterogeneity of the studies was tested for each pooled analysis. Results: Nineteen studies published matched the selection criteria and were included in this meta-analysis. CTCs positivity was significantly associated with poor relapse free survival (RFS) (HR 2.42, 95% CI: [1.94–3.02]; P

Suggested Citation

  • Shuyi Wang & Gang Zheng & Boran Cheng & Fangfang Chen & Zhenmeng Wang & Yuanyuan Chen & You Wang & Bin Xiong, 2014. "Circulating Tumor Cells (CTCs) Detected by RT-PCR and Its Prognostic Role in Gastric Cancer: A Meta-Analysis of Published Literature," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-7, June.
    • Handle: RePEc:plo:pone00:0099259
    DOI: 10.1371/journal.pone.0099259
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    Cited by:

    1. Yunlan Zhou & Bingxian Bian & Xiangliang Yuan & Guohua Xie & Yanhui Ma & Lisong Shen, 2015. "Prognostic Value of Circulating Tumor Cells in Ovarian Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-14, June.

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