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Association between the TERT Genetic Polymorphism rs2853676 and Cancer Risk: Meta-Analysis of 76 108 Cases and 134 215 Controls

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  • Jin-Lin Cao
  • Ping Yuan
  • Abudumailamu Abuduwufuer
  • Wang Lv
  • Yun-Hai Yang
  • Jian Hu

Abstract

Background: Several recent studies have identified that the TERT genetic polymorphism rs2853676 is associated with cancer risk, but presented inconsistent results. We investigated these inconclusive results by performing a meta-analysis to systematically evaluate the association. Methods: We conducted a search in PubMed, Google Scholar and ISI Web of Science to select studies on the association between TERT rs2853676 and cancer risk. We conducted a stratified analysis using cancer type, ethnicity and source of controls. We calculated the odds ratios (OR) and 95% confidence intervals (CI). Article quality, heterogeneity, sensitivity, publication bias and statistical power were also assessed. Results: 26 articles covering 76 108 cases and 134 215 controls met our inclusion criteria. A significant association between TERT rs2853676 allele A and cancer susceptibility was demonstrated under a per-allele risk analysis (OR = 1.08, 95% CI = 1.04-1.13). Stratification analysis revealed an increased cancer risk in subgroups of glioma, lung cancer and ovarian cancer. No significant increase was found in melanoma, breast cancer, pancreatic cancer and colorectal cancer. In a subgroup analysis of lung cancer, a statistically significant increase was only observed in adenocarcinoma. Moreover, a stratified analysis performed for ethnic groups revealed that the significant increase was only observed in Caucasians, whereas a non-significant increase was found in Asians. Conclusions: This meta-analysis suggests that the TERT genetic polymorphism rs2853676 is associated with increased risk of glioma, lung adenocarcinoma and ovarian cancer among Caucasians. Further functional studies are warranted to validate this association and investigate further.

Suggested Citation

  • Jin-Lin Cao & Ping Yuan & Abudumailamu Abuduwufuer & Wang Lv & Yun-Hai Yang & Jian Hu, 2015. "Association between the TERT Genetic Polymorphism rs2853676 and Cancer Risk: Meta-Analysis of 76 108 Cases and 134 215 Controls," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-14, June.
    • Handle: RePEc:plo:pone00:0128829
    DOI: 10.1371/journal.pone.0128829
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    1. Kai Wang & Sharon J. Diskin & Haitao Zhang & Edward F. Attiyeh & Cynthia Winter & Cuiping Hou & Robert W. Schnepp & Maura Diamond & Kristopher Bosse & Patrick A. Mayes & Joseph Glessner & Cecilia Kim , 2011. "Integrative genomics identifies LMO1 as a neuroblastoma oncogene," Nature, Nature, vol. 469(7329), pages 216-220, January.
    2. Haijian Wu & Naian Qiao & Yang Wang & Man Jiang & Shikun Wang & Cuihong Wang & Likuan Hu, 2013. "Association between the Telomerase Reverse Transcriptase (TERT) rs2736098 Polymorphism and Cancer Risk: Evidence from a Case-Control Study of Non-Small-Cell Lung Cancer and a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-10, November.
    3. Andrew J. Gillis & Anthony P. Schuller & Emmanuel Skordalakes, 2008. "Structure of the Tribolium castaneum telomerase catalytic subunit TERT," Nature, Nature, vol. 455(7213), pages 633-637, October.
    4. Eric Bender, 2014. "Developing world: Global warning," Nature, Nature, vol. 509(7502), pages 64-65, May.
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