IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v469y2011i7329d10.1038_nature09609.html
   My bibliography  Save this article

Integrative genomics identifies LMO1 as a neuroblastoma oncogene

Author

Listed:
  • Kai Wang

    (The Center for Applied Genomics, Children’s Hospital of Philadelphia
    Present address: Zilkha Neurogenetic Institute, Department of Psychiatry and Preventive Medicine, University of Southern California, Los Angeles, California 90089, USA.)

  • Sharon J. Diskin

    (Children’s Hospital of Philadelphia)

  • Haitao Zhang

    (The Center for Applied Genomics, Children’s Hospital of Philadelphia)

  • Edward F. Attiyeh

    (Children’s Hospital of Philadelphia)

  • Cynthia Winter

    (Children’s Hospital of Philadelphia)

  • Cuiping Hou

    (The Center for Applied Genomics, Children’s Hospital of Philadelphia)

  • Robert W. Schnepp

    (Children’s Hospital of Philadelphia)

  • Maura Diamond

    (Children’s Hospital of Philadelphia)

  • Kristopher Bosse

    (Children’s Hospital of Philadelphia)

  • Patrick A. Mayes

    (Children’s Hospital of Philadelphia)

  • Joseph Glessner

    (The Center for Applied Genomics, Children’s Hospital of Philadelphia)

  • Cecilia Kim

    (The Center for Applied Genomics, Children’s Hospital of Philadelphia)

  • Edward Frackelton

    (The Center for Applied Genomics, Children’s Hospital of Philadelphia)

  • Maria Garris

    (Children’s Hospital of Philadelphia)

  • Qun Wang

    (Children’s Hospital of Philadelphia)

  • Wendy Glaberson

    (The Center for Applied Genomics, Children’s Hospital of Philadelphia)

  • Rosetta Chiavacci

    (The Center for Applied Genomics, Children’s Hospital of Philadelphia)

  • Le Nguyen

    (Children’s Hospital of Philadelphia
    University of Pennsylvania School of Medicine
    University of Pennsylvania School of Medicine)

  • Jayanti Jagannathan

    (Children’s Hospital of Philadelphia)

  • Norihisa Saeki

    (National Cancer Center Research Institute)

  • Hiroki Sasaki

    (National Cancer Center Research Institute)

  • Struan F. A. Grant

    (The Center for Applied Genomics, Children’s Hospital of Philadelphia
    University of Pennsylvania School of Medicine
    Children’s Hospital of Philadelphia)

  • Achille Iolascon

    (CEINGE Biotecnologie Avanzate
    University of Naples Federico II)

  • Yael P. Mosse

    (Children’s Hospital of Philadelphia
    University of Pennsylvania School of Medicine)

  • Kristina A. Cole

    (Children’s Hospital of Philadelphia
    University of Pennsylvania School of Medicine)

  • Hongzhe Li

    (University of Pennsylvania School of Medicine)

  • Marcella Devoto

    (University of Pennsylvania School of Medicine
    University of Pennsylvania School of Medicine
    Children’s Hospital of Philadelphia
    University La Sapienza)

  • Patrick W. McGrady

    (University of Florida and Children’s Oncology Group)

  • Wendy B. London

    (Dana-Farber Children’s Hospital Cancer Center and Children’s Oncology Group)

  • Mario Capasso

    (CEINGE Biotecnologie Avanzate
    University of Naples Federico II)

  • Nazneen Rahman

    (Section of Cancer Genetics, Institute of Cancer Research)

  • Hakon Hakonarson

    (The Center for Applied Genomics, Children’s Hospital of Philadelphia
    University of Pennsylvania School of Medicine
    Children’s Hospital of Philadelphia)

  • John M. Maris

    (Children’s Hospital of Philadelphia
    University of Pennsylvania School of Medicine)

Abstract

GWAS identifies oncogene A genome-wide association study (GWAS) has shown that single nucleotide variants within the LMO1 locus are associated with inherited susceptibility to neuroblastoma, a childhood cancer of the sympathetic nervous system. LMO1 encodes a transcriptional regulator previously linked to cancers. Acquired structural variation in the same locus is common in patients with neuroblastoma, suggesting that loci identified through GWAS approaches might also be prone to somatic alterations that influence tumour progression. Such studies could help to identify potential therapy targets and/or biomarkers of cancer aggressiveness.

Suggested Citation

  • Kai Wang & Sharon J. Diskin & Haitao Zhang & Edward F. Attiyeh & Cynthia Winter & Cuiping Hou & Robert W. Schnepp & Maura Diamond & Kristopher Bosse & Patrick A. Mayes & Joseph Glessner & Cecilia Kim , 2011. "Integrative genomics identifies LMO1 as a neuroblastoma oncogene," Nature, Nature, vol. 469(7329), pages 216-220, January.
    • Handle: RePEc:nat:nature:v:469:y:2011:i:7329:d:10.1038_nature09609
    DOI: 10.1038/nature09609
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature09609
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature09609?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Lễ B Nguyễn & Sharon J Diskin & Mario Capasso & Kai Wang & Maura A Diamond & Joseph Glessner & Cecilia Kim & Edward F Attiyeh & Yael P Mosse & Kristina Cole & Achille Iolascon & Marcella Devoto & Hako, 2011. "Phenotype Restricted Genome-Wide Association Study Using a Gene-Centric Approach Identifies Three Low-Risk Neuroblastoma Susceptibility Loci," PLOS Genetics, Public Library of Science, vol. 7(3), pages 1-9, March.
    2. Deblina Banerjee & Sukriti Bagchi & Zhihui Liu & Hsien-Chao Chou & Man Xu & Ming Sun & Sara Aloisi & Zalman Vaksman & Sharon J. Diskin & Mark Zimmerman & Javed Khan & Berkley Gryder & Carol J. Thiele, 2024. "Lineage specific transcription factor waves reprogram neuroblastoma from self-renewal to differentiation," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Jin-Lin Cao & Ping Yuan & Abudumailamu Abuduwufuer & Wang Lv & Yun-Hai Yang & Jian Hu, 2015. "Association between the TERT Genetic Polymorphism rs2853676 and Cancer Risk: Meta-Analysis of 76 108 Cases and 134 215 Controls," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-14, June.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:469:y:2011:i:7329:d:10.1038_nature09609. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.