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Integrative genomics identifies LMO1 as a neuroblastoma oncogene

Author

Listed:
  • Kai Wang

    (The Center for Applied Genomics, Children’s Hospital of Philadelphia
    Present address: Zilkha Neurogenetic Institute, Department of Psychiatry and Preventive Medicine, University of Southern California, Los Angeles, California 90089, USA.)

  • Sharon J. Diskin

    (Children’s Hospital of Philadelphia)

  • Haitao Zhang

    (The Center for Applied Genomics, Children’s Hospital of Philadelphia)

  • Edward F. Attiyeh

    (Children’s Hospital of Philadelphia)

  • Cynthia Winter

    (Children’s Hospital of Philadelphia)

  • Cuiping Hou

    (The Center for Applied Genomics, Children’s Hospital of Philadelphia)

  • Robert W. Schnepp

    (Children’s Hospital of Philadelphia)

  • Maura Diamond

    (Children’s Hospital of Philadelphia)

  • Kristopher Bosse

    (Children’s Hospital of Philadelphia)

  • Patrick A. Mayes

    (Children’s Hospital of Philadelphia)

  • Joseph Glessner

    (The Center for Applied Genomics, Children’s Hospital of Philadelphia)

  • Cecilia Kim

    (The Center for Applied Genomics, Children’s Hospital of Philadelphia)

  • Edward Frackelton

    (The Center for Applied Genomics, Children’s Hospital of Philadelphia)

  • Maria Garris

    (Children’s Hospital of Philadelphia)

  • Qun Wang

    (Children’s Hospital of Philadelphia)

  • Wendy Glaberson

    (The Center for Applied Genomics, Children’s Hospital of Philadelphia)

  • Rosetta Chiavacci

    (The Center for Applied Genomics, Children’s Hospital of Philadelphia)

  • Le Nguyen

    (Children’s Hospital of Philadelphia
    University of Pennsylvania School of Medicine
    University of Pennsylvania School of Medicine)

  • Jayanti Jagannathan

    (Children’s Hospital of Philadelphia)

  • Norihisa Saeki

    (National Cancer Center Research Institute)

  • Hiroki Sasaki

    (National Cancer Center Research Institute)

  • Struan F. A. Grant

    (The Center for Applied Genomics, Children’s Hospital of Philadelphia
    University of Pennsylvania School of Medicine
    Children’s Hospital of Philadelphia)

  • Achille Iolascon

    (CEINGE Biotecnologie Avanzate
    University of Naples Federico II)

  • Yael P. Mosse

    (Children’s Hospital of Philadelphia
    University of Pennsylvania School of Medicine)

  • Kristina A. Cole

    (Children’s Hospital of Philadelphia
    University of Pennsylvania School of Medicine)

  • Hongzhe Li

    (University of Pennsylvania School of Medicine)

  • Marcella Devoto

    (University of Pennsylvania School of Medicine
    University of Pennsylvania School of Medicine
    Children’s Hospital of Philadelphia
    University La Sapienza)

  • Patrick W. McGrady

    (University of Florida and Children’s Oncology Group)

  • Wendy B. London

    (Dana-Farber Children’s Hospital Cancer Center and Children’s Oncology Group)

  • Mario Capasso

    (CEINGE Biotecnologie Avanzate
    University of Naples Federico II)

  • Nazneen Rahman

    (Section of Cancer Genetics, Institute of Cancer Research)

  • Hakon Hakonarson

    (The Center for Applied Genomics, Children’s Hospital of Philadelphia
    University of Pennsylvania School of Medicine
    Children’s Hospital of Philadelphia)

  • John M. Maris

    (Children’s Hospital of Philadelphia
    University of Pennsylvania School of Medicine)

Abstract

GWAS identifies oncogene A genome-wide association study (GWAS) has shown that single nucleotide variants within the LMO1 locus are associated with inherited susceptibility to neuroblastoma, a childhood cancer of the sympathetic nervous system. LMO1 encodes a transcriptional regulator previously linked to cancers. Acquired structural variation in the same locus is common in patients with neuroblastoma, suggesting that loci identified through GWAS approaches might also be prone to somatic alterations that influence tumour progression. Such studies could help to identify potential therapy targets and/or biomarkers of cancer aggressiveness.

Suggested Citation

  • Kai Wang & Sharon J. Diskin & Haitao Zhang & Edward F. Attiyeh & Cynthia Winter & Cuiping Hou & Robert W. Schnepp & Maura Diamond & Kristopher Bosse & Patrick A. Mayes & Joseph Glessner & Cecilia Kim , 2011. "Integrative genomics identifies LMO1 as a neuroblastoma oncogene," Nature, Nature, vol. 469(7329), pages 216-220, January.
    • Handle: RePEc:nat:nature:v:469:y:2011:i:7329:d:10.1038_nature09609
    DOI: 10.1038/nature09609
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    Cited by:

    1. Deblina Banerjee & Sukriti Bagchi & Zhihui Liu & Hsien-Chao Chou & Man Xu & Ming Sun & Sara Aloisi & Zalman Vaksman & Sharon J. Diskin & Mark Zimmerman & Javed Khan & Berkley Gryder & Carol J. Thiele, 2024. "Lineage specific transcription factor waves reprogram neuroblastoma from self-renewal to differentiation," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Jin-Lin Cao & Ping Yuan & Abudumailamu Abuduwufuer & Wang Lv & Yun-Hai Yang & Jian Hu, 2015. "Association between the TERT Genetic Polymorphism rs2853676 and Cancer Risk: Meta-Analysis of 76 108 Cases and 134 215 Controls," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-14, June.
    3. Lễ B Nguyễn & Sharon J Diskin & Mario Capasso & Kai Wang & Maura A Diamond & Joseph Glessner & Cecilia Kim & Edward F Attiyeh & Yael P Mosse & Kristina Cole & Achille Iolascon & Marcella Devoto & Hako, 2011. "Phenotype Restricted Genome-Wide Association Study Using a Gene-Centric Approach Identifies Three Low-Risk Neuroblastoma Susceptibility Loci," PLOS Genetics, Public Library of Science, vol. 7(3), pages 1-9, March.
    4. Eun Seop Seo & Ji Won Lee & Jinyeong Lim & Sunghwan Shin & Hee Won Cho & Hee Young Ju & Keon Hee Yoo & Ki Woong Sung & Woong-Yang Park, 2024. "Germline functional variants contribute to somatic mutation and outcomes in neuroblastoma," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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