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Effects of Age and Acute Ethanol on Glutamatergic Neurotransmission in the Medial Prefrontal Cortex of Freely Moving Rats Using Enzyme-Based Microelectrode Amperometry

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  • Devesh Mishra
  • Nicholas R Harrison
  • Carolina B Gonzales
  • Björn Schilström
  • Åsa Konradsson-Geuken

Abstract

Ethanol abuse during adolescence may significantly alter development of the prefrontal cortex which continues to undergo structural remodeling into adulthood. Glutamatergic neurotransmission plays an important role during these brain maturation processes and is modulated by ethanol. In this study, we investigated glutamate dynamics in the medial prefrontal cortex of freely moving rats, using enzyme-based microelectrode amperometry. We analyzed the effects of an intraperitoneal ethanol injection (1 g/kg) on cortical glutamate levels in adolescent and adult rats. Notably, basal glutamate levels decreased with age and these levels were found to be significantly different between postnatal day (PND) 28-38 vs PND 44-55 (p

Suggested Citation

  • Devesh Mishra & Nicholas R Harrison & Carolina B Gonzales & Björn Schilström & Åsa Konradsson-Geuken, 2015. "Effects of Age and Acute Ethanol on Glutamatergic Neurotransmission in the Medial Prefrontal Cortex of Freely Moving Rats Using Enzyme-Based Microelectrode Amperometry," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-15, April.
    • Handle: RePEc:plo:pone00:0125567
    DOI: 10.1371/journal.pone.0125567
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    1. N. Toni & P.-A. Buchs & I. Nikonenko & C. R. Bron & D. Muller, 1999. "LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite," Nature, Nature, vol. 402(6760), pages 421-425, November.
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