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LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite

Author

Listed:
  • N. Toni

    (Neuropharmacology, CMU, University of Geneva)

  • P.-A. Buchs

    (Neuropharmacology, CMU, University of Geneva)

  • I. Nikonenko

    (Neuropharmacology, CMU, University of Geneva)

  • C. R. Bron

    (Institute of Anatomy, University of Bern)

  • D. Muller

    (Neuropharmacology, CMU, University of Geneva)

Abstract

Structural remodelling of synapses1,2,3,4 and formation of new synaptic contacts5,6,7,8 has been postulated as a possible mechanism underlying the late phase of long-term potentiation (LTP), a form of plasticity which is involved in learning and memory9. Here we use electron microscopy to analyse the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines. LTP induction resulted in a sequence of morphological changes consisting of a transient remodelling of the postsynaptic membrane followed by a marked increase in the proportion of axon terminals contacting two or more dendritic spines. Three-dimensional reconstruction revealed that these spines arose from the same dendrite. As pharmacological blockade of LTP prevented these morphological changes, we conclude that LTP is associated with the formation of new, mature and probably functional synapses contacting the same presynaptic terminal and thereby duplicating activated synapses.

Suggested Citation

  • N. Toni & P.-A. Buchs & I. Nikonenko & C. R. Bron & D. Muller, 1999. "LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite," Nature, Nature, vol. 402(6760), pages 421-425, November.
    • Handle: RePEc:nat:nature:v:402:y:1999:i:6760:d:10.1038_46574
    DOI: 10.1038/46574
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    Cited by:

    1. Scott R. Burlingham & Nicole F. Wong & Lindsay Peterkin & Lily Lubow & Carolina Dos Santos Passos & Orion Benner & Michael Ghebrial & Thomas P. Cast & Matthew A. Xu-Friedman & Thomas C. Südhof & Soham, 2022. "Induction of synapse formation by de novo neurotransmitter synthesis," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Tamir Eisenstein & Edna Furman-Haran & Assaf Tal, 2024. "Early excitatory-inhibitory cortical modifications following skill learning are associated with motor memory consolidation and plasticity overnight," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Devesh Mishra & Nicholas R Harrison & Carolina B Gonzales & Björn Schilström & Åsa Konradsson-Geuken, 2015. "Effects of Age and Acute Ethanol on Glutamatergic Neurotransmission in the Medial Prefrontal Cortex of Freely Moving Rats Using Enzyme-Based Microelectrode Amperometry," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-15, April.
    4. Martin Hruska & Rachel E. Cain & Matthew B. Dalva, 2022. "Nanoscale rules governing the organization of glutamate receptors in spine synapses are subunit specific," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    5. Zhiwei Xu & Erez Geron & Luis M. Pérez-Cuesta & Yang Bai & Wen-Biao Gan, 2023. "Generalized extinction of fear memory depends on co-allocation of synaptic plasticity in dendrites," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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