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Plasma Amino Acid Profiling Identifies Specific Amino Acid Associations with Cardiovascular Function in Patients with Systolic Heart Failure

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  • Daihiko Hakuno
  • Yasuhito Hamba
  • Takumi Toya
  • Takeshi Adachi

Abstract

Background: The heart has close interactions with other organs’ functions and concomitant systemic factors such as oxidative stress, nitric oxide (NO), inflammation, and nutrition in systolic heart failure (HF). Recently, plasma amino acid (AA) profiling as a systemic metabolic indicator has attracted considerable attention in predicting the future risk of human cardiometabolic diseases, but it has been scarcely studied in HF. Methods: Thirty-eight stable but greater than New York Heart Association class II symptomatic patients with left ventricular (LV) ejection fraction

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  • Daihiko Hakuno & Yasuhito Hamba & Takumi Toya & Takeshi Adachi, 2015. "Plasma Amino Acid Profiling Identifies Specific Amino Acid Associations with Cardiovascular Function in Patients with Systolic Heart Failure," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-14, February.
    • Handle: RePEc:plo:pone00:0117325
    DOI: 10.1371/journal.pone.0117325
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    Cited by:

    1. Weronika Wasyluk & Patrycja Nowicka-Stążka & Agnieszka Zwolak, 2021. "Heart Metabolism in Sepsis-Induced Cardiomyopathy—Unusual Metabolic Dysfunction of the Heart," IJERPH, MDPI, vol. 18(14), pages 1-20, July.

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