IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0113031.html
   My bibliography  Save this article

HIV Cure Strategies: How Good Must They Be to Improve on Current Antiretroviral Therapy?

Author

Listed:
  • Paul E Sax
  • Alexis Sypek
  • Bethany K Berkowitz
  • Bethany L Morris
  • Elena Losina
  • A David Paltiel
  • Kathleen A Kelly
  • George R Seage III
  • Rochelle P Walensky
  • Milton C Weinstein
  • Joseph Eron
  • Kenneth A Freedberg

Abstract

Background: We examined efficacy, toxicity, relapse, cost, and quality-of-life thresholds of hypothetical HIV cure interventions that would make them cost-effective compared to life-long antiretroviral therapy (ART). Methods: We used a computer simulation model to assess three HIV cure strategies: Gene Therapy, Chemotherapy, and Stem Cell Transplantation (SCT), each compared to ART. Efficacy and cost parameters were varied widely in sensitivity analysis. Outcomes included quality-adjusted life expectancy, lifetime cost, and cost-effectiveness in dollars/quality-adjusted life year ($/QALY) gained. Strategies were deemed cost-effective with incremental cost-effectiveness ratios

Suggested Citation

  • Paul E Sax & Alexis Sypek & Bethany K Berkowitz & Bethany L Morris & Elena Losina & A David Paltiel & Kathleen A Kelly & George R Seage III & Rochelle P Walensky & Milton C Weinstein & Joseph Eron & K, 2014. "HIV Cure Strategies: How Good Must They Be to Improve on Current Antiretroviral Therapy?," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-8, November.
  • Handle: RePEc:plo:pone00:0113031
    DOI: 10.1371/journal.pone.0113031
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113031
    Download Restriction: no

    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0113031&type=printable
    Download Restriction: no

    File URL: https://libkey.io/10.1371/journal.pone.0113031?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Patricia Vold Pepper & Douglas K. Owens, 2002. "Cost-Effectiveness of the Pneumococcal Vaccine in Healthy Younger Adults," Medical Decision Making, , vol. 22(1_suppl), pages 45-57, September.
    2. N. M. Archin & A. L. Liberty & A. D. Kashuba & S. K. Choudhary & J. D. Kuruc & A. M. Crooks & D. C. Parker & E. M. Anderson & M. F. Kearney & M. C. Strain & D. D. Richman & M. G. Hudgens & R. J. Bosch, 2012. "Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy," Nature, Nature, vol. 487(7408), pages 482-485, July.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Donna E. Sweet & Frederick L. Altice & Calvin J. Cohen & Björn Vandewalle, 2016. "Cost-Effectiveness of Single- Versus Generic Multiple-Tablet Regimens for Treatment of HIV-1 Infection in the United States," PLOS ONE, Public Library of Science, vol. 11(1), pages 1-19, January.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ashleigh R Tuite & Ann N Burchell & David N Fisman, 2014. "Cost-Effectiveness of Enhanced Syphilis Screening among HIV-Positive Men Who Have Sex with Men: A Microsimulation Model," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-12, July.
    2. Douglas K. Owens, 2002. "Analytic Tools for Public Health Decision Making," Medical Decision Making, , vol. 22(1_suppl), pages 3-10, September.
    3. Marianela Castillo-Riquelme & Ariel Bardach & Alfredo Palacios & Andrés Pichón-Riviere, 2020. "Health burden and economic costs of smoking in Chile: The potential impact of increasing cigarettes prices," PLOS ONE, Public Library of Science, vol. 15(8), pages 1-16, August.
    4. Hernandez-Vasquez, Akram, 2016. "Burden of smoking-related disease and potential impact of cigarette price increase in Peru," MPRA Paper 75677, University Library of Munich, Germany.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0113031. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.