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Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

Author

Listed:
  • N. M. Archin

    (The University of North Carolina at Chapel Hill)

  • A. L. Liberty

    (The University of North Carolina at Chapel Hill)

  • A. D. Kashuba

    (The University of North Carolina at Chapel Hill)

  • S. K. Choudhary

    (The University of North Carolina at Chapel Hill)

  • J. D. Kuruc

    (The University of North Carolina at Chapel Hill)

  • A. M. Crooks

    (The University of North Carolina at Chapel Hill)

  • D. C. Parker

    (The University of North Carolina at Chapel Hill)

  • E. M. Anderson

    (HIV Drug Resistance Program, NCI, NIH, Frederick, Maryland 21702, USA)

  • M. F. Kearney

    (HIV Drug Resistance Program, NCI, NIH, Frederick, Maryland 21702, USA)

  • M. C. Strain

    (VA San Diego Healthcare System and University of California San Diego)

  • D. D. Richman

    (VA San Diego Healthcare System and University of California San Diego)

  • M. G. Hudgens

    (The University of North Carolina at Chapel Hill)

  • R. J. Bosch

    (Harvard School of Public Health)

  • J. M. Coffin

    (HIV Drug Resistance Program, NCI, NIH, Frederick, Maryland 21702, USA)

  • J. J. Eron

    (The University of North Carolina at Chapel Hill)

  • D. J. Hazuda

    (Merck Research Laboratories)

  • D. M. Margolis

    (The University of North Carolina at Chapel Hill)

Abstract

The latent HIV-1 reservoir represents a major barrier to curing patients with HIV-1 infection, and now in vivo evidence is presented that vorinostat can disrupt proviral latency of HIV-1.

Suggested Citation

  • N. M. Archin & A. L. Liberty & A. D. Kashuba & S. K. Choudhary & J. D. Kuruc & A. M. Crooks & D. C. Parker & E. M. Anderson & M. F. Kearney & M. C. Strain & D. D. Richman & M. G. Hudgens & R. J. Bosch, 2012. "Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy," Nature, Nature, vol. 487(7408), pages 482-485, July.
    • Handle: RePEc:nat:nature:v:487:y:2012:i:7408:d:10.1038_nature11286
    DOI: 10.1038/nature11286
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    Cited by:

    1. Paul E Sax & Alexis Sypek & Bethany K Berkowitz & Bethany L Morris & Elena Losina & A David Paltiel & Kathleen A Kelly & George R Seage III & Rochelle P Walensky & Milton C Weinstein & Joseph Eron & K, 2014. "HIV Cure Strategies: How Good Must They Be to Improve on Current Antiretroviral Therapy?," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-8, November.

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