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An Elevated Peripheral Blood Lymphocyte-to-Monocyte Ratio Predicts Favorable Response and Prognosis in Locally Advanced Breast Cancer following Neoadjuvant Chemotherapy

Author

Listed:
  • Xiao-Jian Ni
  • Xiao-Lan Zhang
  • Qian-Wen Ou-Yang
  • Guo-Wei Qian
  • Lei Wang
  • Sheng Chen
  • Yi-Zhou Jiang
  • Wen-Jia Zuo
  • Jiong Wu
  • Xin Hu
  • Zhi-Ming Shao

Abstract

Purpose: Neoadjuvant chemotherapy (NCT) is a standard treatment option for locally advanced breast cancer. However, the lack of an efficient method to predict treatment response and patient prognosis hampers the clinical evaluation of patient eligibility for NCT. An elevated lymphocyte-to-monocyte ratio (LMR) has been reported to be associated with a favorable prognosis for certain hematologic malignancies and for nasopharyngeal carcinoma; however, this association has not been investigated in breast cancer. The purpose of this study was to evaluate whether pre-NCT LMR analysis could predict the prognosis of patients with locally advanced breast cancer. Methods: A retrospective cohort of 542 locally advanced breast cancer patients (T3/T4 and/or N2/N3 disease) receiving NCT followed by radical surgery was recruited between May 2002 and August 2011 at the Fudan University Shanghai Cancer Center. Counts for pre-NCT peripheral absolute lymphocytes and monocytes were obtained and used to calculate the LMR. Results: Univariate and multivariate analysis revealed that higher LMR levels (≥4.25) were significantly associated with favorable DFS (P = 0.009 and P = 0.011, respectively). Additionally, univariate analysis revealed that a higher lymphocyte count (≥1.5×109/L) showed borderline significance for improved DFS (P = 0.054), while a lower monocyte count (

Suggested Citation

  • Xiao-Jian Ni & Xiao-Lan Zhang & Qian-Wen Ou-Yang & Guo-Wei Qian & Lei Wang & Sheng Chen & Yi-Zhou Jiang & Wen-Jia Zuo & Jiong Wu & Xin Hu & Zhi-Ming Shao, 2014. "An Elevated Peripheral Blood Lymphocyte-to-Monocyte Ratio Predicts Favorable Response and Prognosis in Locally Advanced Breast Cancer following Neoadjuvant Chemotherapy," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-6, November.
    • Handle: RePEc:plo:pone00:0111886
    DOI: 10.1371/journal.pone.0111886
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    1. Zhi-Ming Li & Jia-Jia Huang & Yi Xia & Jian Sun & Ying Huang & Yu Wang & Ying-Jie Zhu & Ya-Jun Li & Wei Zhao & Wen-Xiao Wei & Tong-Yu Lin & Hui-Qiang Huang & Wen-Qi Jiang, 2012. "Blood Lymphocyte-to-Monocyte Ratio Identifies High-Risk Patients in Diffuse Large B-Cell Lymphoma Treated with R-CHOP," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-8, July.
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