IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0102594.html
   My bibliography  Save this article

A New Prognostic Score for Elderly Patients with Diffuse Large B-Cell Lymphoma Treated with R-CHOP: The Prognostic Role of Blood Monocyte and Lymphocyte Counts Is Absent

Author

Listed:
  • Vít Procházka
  • Robert Pytlík
  • Andrea Janíková
  • David Belada
  • David Šálek
  • Tomáš Papajík
  • Vít Campr
  • Tomáš Fürst
  • Jana Furstova
  • Marek Trněný

Abstract

Background: Absolute lymphocyte count (ALC) and absolute monocyte count (AMC) have been documented as independent predictors of survival in patients with newly diagnosed Diffuse Large B-cell Lymphoma (DLBCL). Analysis of the prognostic impact of ALC and AMC in the context of International Prognostic Index (IPI) and other significant variables in elderly population treated in the R-CHOP regime has not been carried out yet. Methodology/Principal Findings: In this retrospective study, a cohort of 443 newly diagnosed DLBCL patients with age ≥60 was analyzed. All patients were treated with the R-CHOP therapy. An extensive statistical analysis was performed to identify risk factors of 3-year overall survival (OS). In multivariate analysis, only three predictors proved significant: Eastern Cooperative Oncology Group performance status (ECOG), age and bulky disease presence. These predictors were dichotomized (ECOG ≥1, age ≥70, bulk ≥7.5) to create a novel four-level score. This score predicted 3-year OS of 94.0%, 77.4%, 62.7% and 35.4% in the low-, low-intermediate, high-intermediate and high-risk groups, respectively (P

Suggested Citation

  • Vít Procházka & Robert Pytlík & Andrea Janíková & David Belada & David Šálek & Tomáš Papajík & Vít Campr & Tomáš Fürst & Jana Furstova & Marek Trněný, 2014. "A New Prognostic Score for Elderly Patients with Diffuse Large B-Cell Lymphoma Treated with R-CHOP: The Prognostic Role of Blood Monocyte and Lymphocyte Counts Is Absent," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-10, July.
    • Handle: RePEc:plo:pone00:0102594
    DOI: 10.1371/journal.pone.0102594
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102594
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0102594&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0102594?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Zhi-Ming Li & Jia-Jia Huang & Yi Xia & Jian Sun & Ying Huang & Yu Wang & Ying-Jie Zhu & Ya-Jun Li & Wei Zhao & Wen-Xiao Wei & Tong-Yu Lin & Hui-Qiang Huang & Wen-Qi Jiang, 2012. "Blood Lymphocyte-to-Monocyte Ratio Identifies High-Risk Patients in Diffuse Large B-Cell Lymphoma Treated with R-CHOP," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-8, July.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Xiao-Jian Ni & Xiao-Lan Zhang & Qian-Wen Ou-Yang & Guo-Wei Qian & Lei Wang & Sheng Chen & Yi-Zhou Jiang & Wen-Jia Zuo & Jiong Wu & Xin Hu & Zhi-Ming Shao, 2014. "An Elevated Peripheral Blood Lymphocyte-to-Monocyte Ratio Predicts Favorable Response and Prognosis in Locally Advanced Breast Cancer following Neoadjuvant Chemotherapy," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-6, November.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0102594. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.