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Association of HLA-DP/DQ and STAT4 Polymorphisms with HBV Infection Outcomes and a Mini Meta-Analysis

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  • Yun Liao
  • Bei Cai
  • Yi Li
  • Jie Chen
  • Chuanmin Tao
  • Hengjian Huang
  • Lanlan Wang

Abstract

Background: Though HLA-DP/DQ is regarded to associate with HBV susceptibility and HBV natural clearance, its role in hepatocellular carcinoma (HCC) development is obscure. And the role of STAT4 in HBV susceptibility and clearance as well as HCC development is still contentious. Therefore, we conducted this study, aiming to clarify these obscure relationships. Methods: We recruited 1312 Chinese Han subjects including healthy controls, HBV carriers and HCC patients in the experiment stage. The meta-analysis included 3467 HCC patients and 5821 HBV carriers to appraise the association with HCC development. Results: Consistent with previous studies, HLA-DP/DQ associated with HBV susceptibility and HBV natural clearance (p

Suggested Citation

  • Yun Liao & Bei Cai & Yi Li & Jie Chen & Chuanmin Tao & Hengjian Huang & Lanlan Wang, 2014. "Association of HLA-DP/DQ and STAT4 Polymorphisms with HBV Infection Outcomes and a Mini Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-9, November.
    • Handle: RePEc:plo:pone00:0111677
    DOI: 10.1371/journal.pone.0111677
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    1. Shengping Li & Ji Qian & Yuan Yang & Wanting Zhao & Juncheng Dai & Jin-Xin Bei & Jia Nee Foo & Paul J McLaren & Zhiqiang Li & Jingmin Yang & Feng Shen & Li Liu & Jiamei Yang & Shuhong Li & Shandong Pa, 2012. "GWAS Identifies Novel Susceptibility Loci on 6p21.32 and 21q21.3 for Hepatocellular Carcinoma in Chronic Hepatitis B Virus Carriers," PLOS Genetics, Public Library of Science, vol. 8(7), pages 1-8, July.
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