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Early Prediction of Intensive Care Unit–Acquired Weakness Using Easily Available Parameters: A Prospective Observational Study

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Listed:
  • Luuk Wieske
  • Esther Witteveen
  • Camiel Verhamme
  • Daniela S Dettling-Ihnenfeldt
  • Marike van der Schaaf
  • Marcus J Schultz
  • Ivo N van Schaik
  • Janneke Horn

Abstract

Introduction: An early diagnosis of Intensive Care Unit–acquired weakness (ICU–AW) using muscle strength assessment is not possible in most critically ill patients. We hypothesized that development of ICU–AW can be predicted reliably two days after ICU admission, using patient characteristics, early available clinical parameters, laboratory results and use of medication as parameters. Methods: Newly admitted ICU patients mechanically ventilated ≥2 days were included in this prospective observational cohort study. Manual muscle strength was measured according to the Medical Research Council (MRC) scale, when patients were awake and attentive. ICU–AW was defined as an average MRC score

Suggested Citation

  • Luuk Wieske & Esther Witteveen & Camiel Verhamme & Daniela S Dettling-Ihnenfeldt & Marike van der Schaaf & Marcus J Schultz & Ivo N van Schaik & Janneke Horn, 2014. "Early Prediction of Intensive Care Unit–Acquired Weakness Using Easily Available Parameters: A Prospective Observational Study," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-8, October.
  • Handle: RePEc:plo:pone00:0111259
    DOI: 10.1371/journal.pone.0111259
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    References listed on IDEAS

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    1. Ewout W. Steyerberg & Marinus J. C. Eijkemans & Frank E. Harrell Jr & J. Dik F. Habbema, 2001. "Prognostic Modeling with Logistic Regression Analysis," Medical Decision Making, , vol. 21(1), pages 45-56, February.
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    1. Tao Yang & Zhi-Qiang Li & Hong-Liang Li & Jian-Xin Zhou & Guang-Qiang Chen, 2020. "Aminoglycoside use and intensive care unit-acquired weakness: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 15(3), pages 1-12, March.

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