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Hyperandrogenemia in Polycystic Ovary Syndrome: Exploration of the Role of Free Testosterone and Androstenedione in Metabolic Phenotype

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  • Elisabeth Lerchbaum
  • Verena Schwetz
  • Thomas Rabe
  • Albrecht Giuliani
  • Barbara Obermayer-Pietsch

Abstract

Objective: To evaluate the association between androstenedione, testosterone, and free testosterone and metabolic disturbances in polycystic ovary syndrome. Methods: We analyzed the association between androstenedione, testosterone, and free testosterone and metabolic parameters in a cross-sectional study including 706 polycystic ovary syndrome and 140 BMI-matched healthy women. Polycystic ovary syndrome women were categorized into 4 groups: normal androstenedione and normal free testosterone (NA/NFT), elevated androstenedione and normal free testosterone (HA/NFT), normal androstenedione and elevated free testosterone (NA/HFT), elevated androstenedione and free testosterone (HA/HFT). Results: Polycystic ovary syndrome women with elevated free testosterone levels (HA/HFT and NA/HFT) have an adverse metabolic profile including 2 h glucose, HbA1c, fasting and 2 h insulin, area under the insulin response curve, insulin resistance, insulin sensitivity index (Matsuda), triglycerides, total and high density lipoprotein cholesterol levels compared to NA/NFT (p

Suggested Citation

  • Elisabeth Lerchbaum & Verena Schwetz & Thomas Rabe & Albrecht Giuliani & Barbara Obermayer-Pietsch, 2014. "Hyperandrogenemia in Polycystic Ovary Syndrome: Exploration of the Role of Free Testosterone and Androstenedione in Metabolic Phenotype," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-12, October.
  • Handle: RePEc:plo:pone00:0108263
    DOI: 10.1371/journal.pone.0108263
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    Cited by:

    1. Roshan Dadachanji & Srabani Mukherjee, 2017. "Polycystic Ovary Syndrome and Cardiovascular Disease: An Enigmatic Relationship," Global Journal of Reproductive Medicine, Juniper Publishers Inc., vol. 1(5), pages 94-99, July.

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