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Polycystic Ovary Syndrome and Cardiovascular Disease: An Enigmatic Relationship

Author

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  • Roshan Dadachanji
  • Srabani Mukherjee

    (Department of Molecular Endocrinology, National Institute for Research in Reproductive Health (ICMR), India)

Abstract

Polycystic Ovary Syndrome (PCOS) is a common endocrinopathy which affects women in reproductive age and is prominently associated with anovulatory infertility. This syndrome is a complex, heterogenous condition with classic manifestations being menstrual irregularities, hirsutism, acne, obesity, insulin resistance, raised LH: FSH ratio and the presence of bulky polycystic ovaries on ultrasound imaging. These women are more susceptible to developing both metabolic and gynecological anomalies including glucose intolerance, dyslipidemias, hypertension, type 2 diabetes Mellitus, and cardiovascular disorders along with endometrial and ovarian cancer. The metabolic milieu in combination with their obesity status and hormonal makeup increases the susceptibility of women with PCOS to critical cardiovascular events in future years. The disparities in CVD outcomes documented may be attributed to the differences in incidence of surrogate markers of cardiovascular disease in women with PCOS showing ethnic and phenotypic variability. The onset of cardiometabolic derangements may manifest in adolescence itself and early diagnosis and monitoring of markers of cardiovascular disease should be emphasized early on to prevent severe long term consequences.

Suggested Citation

  • Roshan Dadachanji & Srabani Mukherjee, 2017. "Polycystic Ovary Syndrome and Cardiovascular Disease: An Enigmatic Relationship," Global Journal of Reproductive Medicine, Juniper Publishers Inc., vol. 1(5), pages 94-99, July.
    • Handle: RePEc:adp:jgjorm:v:1:y:2017:i:5:p:94-99
    DOI: 10.19080/GJORM.2017.01.555571
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    References listed on IDEAS

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    1. Elisabeth Lerchbaum & Verena Schwetz & Thomas Rabe & Albrecht Giuliani & Barbara Obermayer-Pietsch, 2014. "Hyperandrogenemia in Polycystic Ovary Syndrome: Exploration of the Role of Free Testosterone and Androstenedione in Metabolic Phenotype," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-12, October.
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