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Association of Neuropeptide Y (NPY), Interleukin-1B (IL1B) Genetic Variants and Correlation of IL1B Transcript Levels with Vitiligo Susceptibility

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Listed:
  • Naresh C Laddha
  • Mitesh Dwivedi
  • Mohmmad Shoab Mansuri
  • Mala Singh
  • Hetanshi H Patel
  • Nishtha Agarwal
  • Anish M Shah
  • Rasheedunnisa Begum

Abstract

Background: Vitiligo is a depigmenting disorder resulting from loss of functional melanocytes in the skin. NPY plays an important role in induction of immune response by acting on a variety of immune cells. NPY synthesis and release is governed by IL1B. Moreover, genetic variability in IL1B is reported to be associated with elevated NPY levels. Objectives: Aim of the present study was to explore NPY promoter −399T/C (rs16147) and exon2 +1128T/C (rs16139) polymorphisms as well as IL1B promoter −511C/T (rs16944) polymorphism and to correlate IL1B transcript levels with vitiligo. Methods: PCR-RFLP method was used to genotype NPY -399T/C SNP in 454 patients and 1226 controls; +1128T/C SNP in 575 patients and 1279 controls and IL1B −511C/T SNP in 448 patients and 785 controls from Gujarat. IL1B transcript levels in blood were also assessed in 105 controls and 95 patients using real-time PCR. Results: Genotype and allele frequencies for NPY −399T/C, +1128T/C and IL1B −511C/T SNPs differed significantly (p

Suggested Citation

  • Naresh C Laddha & Mitesh Dwivedi & Mohmmad Shoab Mansuri & Mala Singh & Hetanshi H Patel & Nishtha Agarwal & Anish M Shah & Rasheedunnisa Begum, 2014. "Association of Neuropeptide Y (NPY), Interleukin-1B (IL1B) Genetic Variants and Correlation of IL1B Transcript Levels with Vitiligo Susceptibility," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-11, September.
    • Handle: RePEc:plo:pone00:0107020
    DOI: 10.1371/journal.pone.0107020
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    1. Zhifeng Zhou & Guanshan Zhu & Ahmad R. Hariri & Mary-Anne Enoch & David Scott & Rajita Sinha & Matti Virkkunen & Deborah C. Mash & Robert H. Lipsky & Xian-Zhang Hu & Colin A. Hodgkinson & Ke Xu & Beat, 2008. "Genetic variation in human NPY expression affects stress response and emotion," Nature, Nature, vol. 452(7190), pages 997-1001, April.
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