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Genetic variation in human NPY expression affects stress response and emotion

Author

Listed:
  • Zhifeng Zhou

    (Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA)

  • Guanshan Zhu

    (Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
    Present address: Innovation Centre China, AstraZeneca Global R&D, Shanghai 201203, China.)

  • Ahmad R. Hariri

    (Human Genetics, and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA)

  • Mary-Anne Enoch

    (Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA)

  • David Scott

    (University of Michigan Medical School, Ann Arbor, Michigan 48109, USA)

  • Rajita Sinha

    (Yale University School of Medicine, New Haven, Connecticut 06510, USA)

  • Matti Virkkunen

    (University of Helsinki, 00014, Helsinki, Finland)

  • Deborah C. Mash

    (University of Miami School of Medicine, Miami, Florida 33124, USA)

  • Robert H. Lipsky

    (Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA)

  • Xian-Zhang Hu

    (Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA)

  • Colin A. Hodgkinson

    (Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA)

  • Ke Xu

    (Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA)

  • Beata Buzas

    (Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA)

  • Qiaoping Yuan

    (Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA)

  • Pei-Hong Shen

    (Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA)

  • Robert E. Ferrell

    (Human Genetics, and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA)

  • Stephen B. Manuck

    (Human Genetics, and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA)

  • Sarah M. Brown

    (Human Genetics, and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA)

  • Richard L. Hauger

    (San Diego VA Healthcare System and University of California, San Diego, California 92161, USA)

  • Christian S. Stohler

    (School of Dentistry, University of Maryland, Baltimore, Maryland 21201, USA)

  • Jon-Kar Zubieta

    (University of Michigan Medical School, Ann Arbor, Michigan 48109, USA)

  • David Goldman

    (Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA)

Abstract

The Y factor An individual's ability to deal with stress and anxiety — risk factors for many diseases — varies widely across human populations and the factors contributing to emotional resilience are complex. A study led by researchers at the National Institute on Alcohol Abuse and Alcoholism now points to inherited variations in the expression of the natural anxiolytic peptide neuropeptide Y in the brain as a factor in determining why some people can withstand stress better than others.

Suggested Citation

  • Zhifeng Zhou & Guanshan Zhu & Ahmad R. Hariri & Mary-Anne Enoch & David Scott & Rajita Sinha & Matti Virkkunen & Deborah C. Mash & Robert H. Lipsky & Xian-Zhang Hu & Colin A. Hodgkinson & Ke Xu & Beat, 2008. "Genetic variation in human NPY expression affects stress response and emotion," Nature, Nature, vol. 452(7190), pages 997-1001, April.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7190:d:10.1038_nature06858
    DOI: 10.1038/nature06858
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    Cited by:

    1. Sonu Peedikayil-Kurien & Rizwanul Haque & Asaf Gat & Meital Oren-Suissa, 2025. "Modulation by NPY/NPF-like receptor underlies experience-dependent, sexually dimorphic learning," Nature Communications, Nature, vol. 16(1), pages 1-16, December.
    2. Naresh C Laddha & Mitesh Dwivedi & Mohmmad Shoab Mansuri & Mala Singh & Hetanshi H Patel & Nishtha Agarwal & Anish M Shah & Rasheedunnisa Begum, 2014. "Association of Neuropeptide Y (NPY), Interleukin-1B (IL1B) Genetic Variants and Correlation of IL1B Transcript Levels with Vitiligo Susceptibility," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-11, September.

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