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Association between CD14 Gene Polymorphisms and Cancer Risk: A Meta-Analysis

Author

Listed:
  • Jun Wang
  • Xufeng Guo
  • Shijie Yu
  • Jia Song
  • Jixiang Zhang
  • Zhuo Cao
  • Jing Wang
  • Min Liu
  • Weiguo Dong

Abstract

Background: Two polymorphisms, -260C/T and -651C/T, in the CD14 gene have been implicated in susceptibility to cancer. However, the results remain inconclusive. This meta-analysis aimed to investigate the association between the two polymorphisms and risk of cancer. Methods: All eligible case-control studies published up to March 2014 were identified by searching PubMed, Web of Science, CNKI and WanFang database. Pooled odds ratio (OR) with 95% confidence interval (CI) were used to access the strength of this association in fixed- or random-effects model. Results: 17 case-control studies from fourteen articles were included. Of those, there were 17 studies (4198 cases and 4194 controls) for -260C/T polymorphism and three studies (832 cases and 1190 controls) for -651C/T polymorphism. Overall, no significant associations between the two polymorphisms of CD14 gene and cancer risk were found. When stratified by ethnicity, cancer type and source of control, similar results were observed among them. In addition, in further subgroups analysis by Helicobacter pylori (H. pylori) infection status and tumor location in gastric cancer subgroup, we found that the CD14 -260C/T polymorphism may increase the risk of gastric cancer in H. pylori-infected individuals. Conclusions: This meta-analysis suggests that the CD14 -260C/T polymorphism may increase the risk of gastric cancer in H. pylori-infected individuals. However, large and well-designed studies are warranted to validate our findings.

Suggested Citation

  • Jun Wang & Xufeng Guo & Shijie Yu & Jia Song & Jixiang Zhang & Zhuo Cao & Jing Wang & Min Liu & Weiguo Dong, 2014. "Association between CD14 Gene Polymorphisms and Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-9, June.
    • Handle: RePEc:plo:pone00:0100122
    DOI: 10.1371/journal.pone.0100122
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    References listed on IDEAS

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    1. Natalia Castaño-Rodríguez & Nadeem O Kaakoush & Khean-Lee Goh & Kwong Ming Fock & Hazel M Mitchell, 2013. "The Role of TLR2, TLR4 and CD14 Genetic Polymorphisms in Gastric Carcinogenesis: A Case-Control Study and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-12, April.
    2. An-qiang Zhang & Cai-li Yue & Wei Gu & Juan Du & Hai-yan Wang & Jianxin Jiang, 2013. "Association between CD14 Promoter -159C/T Polymorphism and the Risk of Sepsis and Mortality: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-9, August.
    3. Zhengting Wang & Jiajia Hu & Rong Fan & Jie Zhou & Jie Zhong, 2012. "Association between CD14 Gene C-260T Polymorphism and Inflammatory Bowel Disease: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-7, September.
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