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Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 Polymorphisms Are Associated with Decreased Risk of Esophageal Squamous Cell Carcinoma in Chinese Populations

Author

Listed:
  • Junjie Zhang
  • Xuewen Huang
  • Juanjuan Xiao
  • Yajun Yang
  • Yinghui Zhou
  • Xiaofeng Wang
  • Qingmei Liu
  • Jingmin Yang
  • Mengyun Wang
  • Lixin Qiu
  • Yabiao Zheng
  • Ping Zhang
  • Jin Li
  • Ya’nong Wang
  • Qingyi Wei
  • Li Jin
  • Jiucun Wang
  • Minghua Wang

Abstract

MicroRNAs are a new class of small non-protein-coding RNAs that sometimes function as tumor suppressors or oncogenes. Aberrant expression and structural alteration of microRNAs have been reported to be involved in tumorigenesis and cancer development. Recently, rs531564/pri-miR-124-1, rs4938723/pri-miR-34b/c, rs7372209/pri-miR-26a-1, rs895819/pre-miR-27a, and rs11134527/pri-miR-218 were reported to be associated with risks of various cancers. In order to evaluate the relationship of these SNPs and esophageal squamous cell carcinoma (ESCC) risk, we conducted a case-control study with 1109 ESCC patients and 1275 control subjects to examine the potential association of these pri/pre-miRNA polymorphisms with ESCC susceptibility. As a result, two SNPs were associated with a significant risk of ESCC. We found that the GG genotype of pri-miR-124-1 rs531564 was associated to a significantly decreased risk of ESCC comparing with the CC/CG genotypes (p = 0.005; OR = 0.61, 95% CI = 0.43–0.86). In addition, the CC genotype of pri-miR-34b/c rs4938723 was associated with a significant decreased risk of ESCC (CC VS. TT/TC: p = 0.007, OR = 0.82, 95% CI = 0.71–0.95) in Chinese population. The present study provides the first evidence that pri-miR-124-1 rs531564 and pri-miR-34 rs4938723 were associated with the risk of ESCC in Chinese population.

Suggested Citation

  • Junjie Zhang & Xuewen Huang & Juanjuan Xiao & Yajun Yang & Yinghui Zhou & Xiaofeng Wang & Qingmei Liu & Jingmin Yang & Mengyun Wang & Lixin Qiu & Yabiao Zheng & Ping Zhang & Jin Li & Ya’nong Wang & Qi, 2014. "Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 Polymorphisms Are Associated with Decreased Risk of Esophageal Squamous Cell Carcinoma in Chinese Populations," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-7, June.
    • Handle: RePEc:plo:pone00:0100055
    DOI: 10.1371/journal.pone.0100055
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    1. Richard I. Gregory & Kai-ping Yan & Govindasamy Amuthan & Thimmaiah Chendrimada & Behzad Doratotaj & Neil Cooch & Ramin Shiekhattar, 2004. "The Microprocessor complex mediates the genesis of microRNAs," Nature, Nature, vol. 432(7014), pages 235-240, November.
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