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Association between Polymorphism of Exportin-5 and Susceptibility to Lead Poisoning in a Chinese Population

Author

Listed:
  • Hengdong Zhang

    (Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, No. 199 Renai Road, Suzhou Industrial Park, Suzhou 215123, China
    Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210028, China)

  • Ming Xu

    (Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210028, China)

  • Qiuni Zhao

    (School of Public Health, Southeast University, Nanjing 210009, China)

  • Kai Sun

    (Department of Emergency Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210009, China)

  • Wei Gong

    (Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210028, China)

  • Qiaoyun Zhang

    (Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210028, China)

  • Baoli Zhu

    (Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210028, China
    School of Public Health, Southeast University, Nanjing 210009, China)

  • Yan An

    (Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, No. 199 Renai Road, Suzhou Industrial Park, Suzhou 215123, China)

Abstract

Lead ( Pb ) is one of the major contaminants in many industries, and imposes hazardous effects on multiple human organs and systems. Studies have shown that lead is able to induce the alteration of microRNA (miRNA) expression in serum and organs. In this study we investigated whether polymorphisms in miRNA-regulating genes were associated with the risk of lead exposure. We genotyped seven single-nucleotide polymorphisms (SNPs) in 113 lead-sensitive and 113 lead-resistant lead-related Chinese workers by Taqman analysis. The lead-sensitive group showed a significantly higher blood lead level (BLL) than the resistant group based on unconditional logistic regression results. One SNP in XPO5 extron (rs2257082) was significantly associated with lead-poisoning ( p = 0.022, odds rate (OR) = 1.63, 95% confidence interval (CI) = 1.07–2.47 in the C allele compared to the T allele). There were no significant associations between the other six SNPs and the blood lead levels. Therefore, polymorphism rs2257082 could be used to distinguish lead-resistant and lead-susceptible populations, and to develop more specific and accurate preventions.

Suggested Citation

  • Hengdong Zhang & Ming Xu & Qiuni Zhao & Kai Sun & Wei Gong & Qiaoyun Zhang & Baoli Zhu & Yan An, 2016. "Association between Polymorphism of Exportin-5 and Susceptibility to Lead Poisoning in a Chinese Population," IJERPH, MDPI, vol. 14(1), pages 1-8, December.
    • Handle: RePEc:gam:jijerp:v:14:y:2016:i:1:p:36-:d:86647
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    References listed on IDEAS

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    1. Richard I. Gregory & Kai-ping Yan & Govindasamy Amuthan & Thimmaiah Chendrimada & Behzad Doratotaj & Neil Cooch & Ramin Shiekhattar, 2004. "The Microprocessor complex mediates the genesis of microRNAs," Nature, Nature, vol. 432(7014), pages 235-240, November.
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