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Is Treatment with Trimetazidine Beneficial in Patients with Chronic Heart Failure?

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  • Xiang Zhou
  • Jianchang Chen

Abstract

Background: Whether additional benefit can be achieved with the use of trimetazidine (TMZ) in patients with chronic heart failure (CHF) remains controversial. We therefore performed a meta-analysis of randomized controlled trials (RCTs) to evaluate the effects of TMZ treatment in CHF patients. Methods: We searched PubMed, EMBASE, and Cochrane databases through October 2013 and included 19 RCTs involving 994 CHF patients who underwent TMZ or placebo treatment. Risk ratio (RR) and weighted mean differences (WMD) were calculated using fixed or random effects models. Results: TMZ therapy was associated with considerable improvement in left ventricular ejection fraction (WMD: 7.29%, 95% CI: 6.49 to 8.09, p

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  • Xiang Zhou & Jianchang Chen, 2014. "Is Treatment with Trimetazidine Beneficial in Patients with Chronic Heart Failure?," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-10, May.
    • Handle: RePEc:plo:pone00:0094660
    DOI: 10.1371/journal.pone.0094660
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    Cited by:

    1. Ying Zhang & Xiao-juan Ma & Da-zhuo Shi, 2015. "Effect of Trimetazidine in Patients Undergoing Percutaneous Coronary Intervention: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-11, September.
    2. Narges A Albibas & Osama A Bheleel & Fathi M Sherif, 2017. "The Effect of Chronic Trimetazidine Administration on Left Ventricular Function and Quality Of Life in Libyan Patients with Heart Failure," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 1(1), pages 130-137, June.

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