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Dietary Mushroom Intake May Reduce the Risk of Breast Cancer: Evidence from a Meta-Analysis of Observational Studies

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  • Jiaoyuan Li
  • Li Zou
  • Wei Chen
  • Beibei Zhu
  • Na Shen
  • Juntao Ke
  • Jiao Lou
  • Ranran Song
  • Rong Zhong
  • Xiaoping Miao

Abstract

Epidemiological studies have investigated the potential anticancer effects of mushroom intake. This review aims to clarify the evidence on the association of dietary mushroom intake with breast cancer risk and to quantify its dose-response relationship. Relevant studies were identified by a search of PubMed, Web of Science and Google Scholar up to December 31, 2013. Observational studies with relative risks (RRs) or hazard ratios (HRs) or odd ratios (ORs) and 95% confidence intervals (CIs) of breast cancer for three or more categories of mushroom intake were eligible. The quality of included studies was assessed by using Newcastle-Ottawa Scale. A dose-response meta-analysis was performed by utilizing generalized least squares trend estimation. Eight case-control studies and two cohort studies with a total of 6890 cases were ultimately included. For dose-response analysis, there was no evidence of non-linear association between mushroom consumption and breast cancer risk (P = 0.337) and a 1 g/d increment in mushroom intake conferred an RR of 0.97 (95% CI: 0.96–0.98) for breast cancer risk, with moderate heterogeneity (I2 = 56.3%, P = 0.015). Besides, available menopause data extracted from included studies were used to evaluate the influence of menopausal statues. The summary RRs of mushroom consumption on breast cancer were 0.96 (95% CI: 0.91–1.00) for premenopausal women and 0.94 (95% CI: 0.91–0.97) for postmenopausal women, respectively. Our findings demonstrated that mushroom intake may be inversely associated with risk of breast cancer, which need to be confirmed with large-scale prospective studies further.

Suggested Citation

  • Jiaoyuan Li & Li Zou & Wei Chen & Beibei Zhu & Na Shen & Juntao Ke & Jiao Lou & Ranran Song & Rong Zhong & Xiaoping Miao, 2014. "Dietary Mushroom Intake May Reduce the Risk of Breast Cancer: Evidence from a Meta-Analysis of Observational Studies," PLOS ONE, Public Library of Science, vol. 9(4), pages 1-8, April.
  • Handle: RePEc:plo:pone00:0093437
    DOI: 10.1371/journal.pone.0093437
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    References listed on IDEAS

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    1. Julian Peto, 2001. "Cancer epidemiology in the last century and the next decade," Nature, Nature, vol. 411(6835), pages 390-395, May.
    2. Qibin Song & Beibei Zhu & Weiguo Hu & Liming Cheng & Hongyun Gong & Bin Xu & Xiawen Zheng & Li Zou & Rong Zhong & Shengyu Duan & Wei Chen & Rui Rui & Jing Wu & Xiaoping Miao, 2012. "A Common SMAD7 Variant Is Associated with Risk of Colorectal Cancer: Evidence from a Case-Control Study and a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(3), pages 1-8, March.
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