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Latent TB Infection Diagnosis in Population Exposed to TB Subjects in Close and Poor Ventilated High TB Endemic Zone in India

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Listed:
  • Rajpal S Kashyap
  • Amit R Nayak
  • Hari M Gaherwar
  • Aliabbas A Husain
  • Seema D Shekhawat
  • Ruchika K Jain
  • Milind S Panchbhai
  • Dhananjay V Raje
  • Hemant J Purohit
  • Girdhar M Taori
  • Hatim F Daginawala

Abstract

Background: The present study was designed to investigate the utility of Quantiferon TB gold (QFT-G) and Tuberculin skin test (TST) for diagnosis of latent TB infection (LTBI) in high crowding TB endemic zone of Nagpur, India and their comparison with associated risk factors. Methods: Out of 342 eligible participants, QFT-G and TST were performed in 162 participants. Results: The prevalence of LTBI observed according to QFT-G and TST was 48% and 42% respectively, with an agreement of 52.47%. QFT-G positivity was associated with age while TST positivity was associated with body mass index (BMI). Duration of exposure emerged as a key risk factor significantly associated with both the tests. Conclusion: The prevalence of LTBI was quite high in the studied zone as detected by both the evaluated tests and thus, the combination of both the tests will be best predictive for LTBI in such high TB endemic regions.

Suggested Citation

  • Rajpal S Kashyap & Amit R Nayak & Hari M Gaherwar & Aliabbas A Husain & Seema D Shekhawat & Ruchika K Jain & Milind S Panchbhai & Dhananjay V Raje & Hemant J Purohit & Girdhar M Taori & Hatim F Dagina, 2014. "Latent TB Infection Diagnosis in Population Exposed to TB Subjects in Close and Poor Ventilated High TB Endemic Zone in India," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-10, March.
    • Handle: RePEc:plo:pone00:0089524
    DOI: 10.1371/journal.pone.0089524
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    References listed on IDEAS

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    1. Albert Nienhaus & Anja Schablon & Roland Diel, 2008. "Interferon-Gamma Release Assay for the Diagnosis of Latent TB Infection – Analysis of Discordant Results, when Compared to the Tuberculin Skin Test," PLOS ONE, Public Library of Science, vol. 3(7), pages 1-6, July.
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