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Association of Fas -1377 G/A Polymorphism with Susceptibility to Cancer

Author

Listed:
  • Peiliang Geng
  • Jianjun Li
  • Juanjuan Ou
  • Ganfeng Xie
  • Ning Wang
  • Lisha Xiang
  • Rina Sa
  • Chen Liu
  • Hongtao Li
  • Houjie Liang

Abstract

Background: The relationship between Fas -1377 G/A polymorphism and cancer susceptibility has been implicated in accumulating data. However, the data presented inconsistent results. This study was devised to investigate the association of Fas -1377 G/A polymorphism and cancer susceptibility in a large number of participants. Methods: The databases of PubMed, Embase, and Web of Science were searched and a total of 27 case-control studies including 13,355 cases and 16,078 controls were included in this meta-analysis. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using the fixed-effects model. Statistical analyses were performed by using Stata software. Results: The results suggested that Fas -1377 G/A polymorphism was overall associated with cancer susceptibility (additive model: OR, 1.16, 95%CI = 1.06–1.27, Pheterogeneity = 0.381; recessive model: OR, 1.19, 95%CI = 1.10–1.29, Pheterogeneity = 0.137). In the subgroup analysis by cancer type, significantly increased risk was observed in breast cancer (additive model: OR, 1.24, 95%CI = 1.04–1.58, Pheterogeneity = 0.614; recessive model: OR, 1.24, 95%CI = 1.02–1.51, Pheterogeneity = 0.349) and lung cancer (recessive model: OR, 1.25, 95%CI = 1.04–1.49, Pheterogeneity = 0.090). Similarly, elevated cancer risk associated with Fas -1377 G/A polymorphism was revealed in Asians. Conclusions: The combined results suggest that Fas -1377 G/A polymorphism might modulate cancer susceptibility in an Asian-specific manner.

Suggested Citation

  • Peiliang Geng & Jianjun Li & Juanjuan Ou & Ganfeng Xie & Ning Wang & Lisha Xiang & Rina Sa & Chen Liu & Hongtao Li & Houjie Liang, 2014. "Association of Fas -1377 G/A Polymorphism with Susceptibility to Cancer," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-8, February.
    • Handle: RePEc:plo:pone00:0088748
    DOI: 10.1371/journal.pone.0088748
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    References listed on IDEAS

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    1. Jan H. J. Hoeijmakers, 2001. "Genome maintenance mechanisms for preventing cancer," Nature, Nature, vol. 411(6835), pages 366-374, May.
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