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Genome maintenance mechanisms for preventing cancer

Author

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  • Jan H. J. Hoeijmakers

    (Centre for Biomedical Genetics, Erasmus University)

Abstract

The early notion that cancer is caused by mutations in genes critical for the control of cell growth implied that genome stability is important for preventing oncogenesis. During the past decade, knowledge about the mechanisms by which genes erode and the molecular machinery designed to counteract this time-dependent genetic degeneration has increased markedly. At the same time, it has become apparent that inherited or acquired deficiencies in genome maintenance systems contribute significantly to the onset of cancer. This review summarizes the main DNA caretaking systems and their impact on genome stability and carcinogenesis.

Suggested Citation

  • Jan H. J. Hoeijmakers, 2001. "Genome maintenance mechanisms for preventing cancer," Nature, Nature, vol. 411(6835), pages 366-374, May.
    • Handle: RePEc:nat:nature:v:411:y:2001:i:6835:d:10.1038_35077232
    DOI: 10.1038/35077232
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    1. Rui-Xi Hua & He-Ping Li & Yan-Bing Liang & Jin-Hong Zhu & Bing Zhang & Sheng Ye & Qiang-Sheng Dai & Shi-Qiu Xiong & Yong Gu & Xiang-Zhou Sun, 2014. "Association between the PARP1 Val762Ala Polymorphism and Cancer Risk: Evidence from 43 Studies," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-9, January.
    2. Yin Lou & Wen-jia Peng & Dong-sheng Cao & Juan Xie & Hong-hong Li & Zheng-xuan Jiang, 2013. "DNA Repair Gene XRCC1 Polymorphisms and Head and Neck Cancer Risk: An Updated Meta-Analysis Including 16344 Subjects," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-1, September.
    3. Blasi, Monica Francesca & Casorelli, Ida & Colosimo, Alfredo & Blasi, Francesco Simone & Bignami, Margherita & Giuliani, Alessandro, 2005. "A recursive network approach can identify constitutive regulatory circuits in gene expression data," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 348(C), pages 349-370.
    4. Peiliang Geng & Jianjun Li & Juanjuan Ou & Ganfeng Xie & Ning Wang & Lisha Xiang & Rina Sa & Chen Liu & Hongtao Li & Houjie Liang, 2014. "Association of Fas -1377 G/A Polymorphism with Susceptibility to Cancer," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-8, February.
    5. Ronan Broderick & Sivaramakrishnan Ramadurai & Katalin Tóth & Denisio M Togashi & Alan G Ryder & Jörg Langowski & Heinz Peter Nasheuer, 2012. "Cell Cycle-Dependent Mobility of Cdc45 Determined in vivo by Fluorescence Correlation Spectroscopy," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-10, April.
    6. Hongtuan Zhang & Hui Ma & Liang Li & Zhihong Zhang & Yong Xu, 2013. "Association of Methylenetetrahydrofolate Dehydrogenase 1 Polymorphisms with Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-7, July.
    7. Bian Wu & Hong-Li Liu & Sheng Zhang & Xiao-Rong Dong & Gang Wu, 2012. "Lack of an Association between Two BER Gene Polymorphisms and Breast Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-7, December.
    8. Yong-qiang Wang & Xiao-wei Qi & Fan Wang & Jun Jiang & Qiao-nan Guo, 2012. "Association between TGFBR1 Polymorphisms and Cancer Risk: A Meta-Analysis of 35 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-10, August.
    9. Guohua Huang & Shaoxi Cai & Wei Wang & Qing Zhang & Aihua Liu, 2013. "Association between XRCC1 and XRCC3 Polymorphisms with Lung Cancer Risk: A Meta-Analysis from Case-Control Studies," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-13, August.
    10. Qing Yan & Pin Chen & Ailin Lu & Peng Zhao & Aihua Gu, 2013. "Association between CTLA-4 60G/A and -1661A/G Polymorphisms and the Risk of Cancers: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-9, December.
    11. Simão, Éder M. & Cabral, Heleno B. & Castro, Mauro A.A. & Sinigaglia, Marialva & Mombach, José C.M. & Librelotto, Giovani R., 2010. "Modeling the Human Genome Maintenance network," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 389(19), pages 4188-4194.
    12. Tao Bu & Li Liu & Yong Sun & Li Zhao & Yang Peng & Shudong Zhou & Lixia Li & Sidong Chen & Yanhui Gao, 2014. "XRCC1 Arg399Gln Polymorphism Confers Risk of Breast Cancer in American Population: A Meta-Analysis of 10846 Cases and 11723 Controls," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-9, January.
    13. Hong Chen & Lin Ge & Qiuli Sui & Mei Lin, 2015. "Systematic Review and Meta-Analysis of the Relationship between EPHX1 Polymorphisms and the Risk of Head and Neck Cancer," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-15, April.
    14. Mengmeng Zhao & Pin Chen & Yanbin Dong & Xianji Zhu & Xilong Zhang, 2014. "Relationship between Rad51 G135C and G172T Variants and the Susceptibility to Cancer: A Meta-Analysis Involving 54 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-11, January.
    15. Qin Qin & Jing Lu & Hongcheng Zhu & Liping Xu & Hongyan Cheng & Liangliang Zhan & Xi Yang & Chi Zhang & Xinchen Sun, 2014. "PARP-1 Val762Ala Polymorphism and Risk of Cancer: A Meta-Analysis Based on 39 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-12, May.

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