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Associations of MTHFR Gene Polymorphisms with Hypertension and Hypertension in Pregnancy: A Meta-Analysis from 114 Studies with 15411 Cases and 21970 Controls

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  • Boyi Yang
  • Shujun Fan
  • Xueyuan Zhi
  • Yongfang Li
  • Yuyan Liu
  • Da Wang
  • Miao He
  • Yongyong Hou
  • Quanmei Zheng
  • Guifan Sun

Abstract

Background: Several epidemiological studies have investigated the associations of methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms with hypertension (H) or hypertension in pregnancy (HIP). However, the results were controversial. We therefore performed a comprehensive meta-analysis to provide empirical evidences on the associations. Methodologies: The English and Chinese databases were systematically searched to identify relevant studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the associations. Meta-regression, subgroup analysis, sensitivity analysis, cumulative meta-analysis and assessment of publication bias were performed in our study. Principal Findings: A total of 114 studies with 15411 cases and 21970 controls were included, 111 studies with 15094 cases and 21633 controls for the C677T polymorphism and 21 with 2533 cases and 2976 controls for the A1298C polymorphism. Overall, the C677T polymorphism was significantly associated with H and HIP (H & HIP: OR = 1.26, 95% CI = 1.17–1.34; H: OR = 1.36, 95% CI = 1.20–1.53; HIP: OR = 1.21, 95% CI = 1.08–1.32). Stratified analysis by ethnicity revealed a significant association among East Asians and Caucasians, but not among Latinos, Black Africans, and Indians and Sri Lankans. In the stratified analyses according to source of controls, genotyping method, sample size and study quality, significant associations were observed in all the subgroups, with the exception of population based subgroup in H studies and large sample size and “others” genotyping method subgroups in HIP studies. For the A1298C polymorphism, no significant association was observed either in overall or subgroup analysis under all genetic models. Conclusions: This meta-analysis suggests that the MTHFR C677T rather than A1298C polymorphism may be associated with H & HIP, especially among East Asians and Caucasians.

Suggested Citation

  • Boyi Yang & Shujun Fan & Xueyuan Zhi & Yongfang Li & Yuyan Liu & Da Wang & Miao He & Yongyong Hou & Quanmei Zheng & Guifan Sun, 2014. "Associations of MTHFR Gene Polymorphisms with Hypertension and Hypertension in Pregnancy: A Meta-Analysis from 114 Studies with 15411 Cases and 21970 Controls," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-1, February.
    • Handle: RePEc:plo:pone00:0087497
    DOI: 10.1371/journal.pone.0087497
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    References listed on IDEAS

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    1. Yuan Zhao & Zixian Chen & Yushui Ma & Qing Xia & Feng Zhang & Da Fu & Xiao-Feng Wang, 2013. "Lack of Association between Methionine Synthase A2756G Polymorphism and Digestive System Cancer Risk: Evidence from 39327 Subjects," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-7, April.
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    Cited by:

    1. Shujun Fan & Boyi Yang & Xueyuan Zhi & Yanxun Wang & Jian Wei & Quanmei Zheng & Guifan Sun, 2016. "Interactions of Methylenetetrahydrofolate Reductase C677T Polymorphism with Environmental Factors on Hypertension Susceptibility," IJERPH, MDPI, vol. 13(6), pages 1-13, June.
    2. Ya-Ling Yang & Hsiao-Ling Yang & S. Pamela K. Shiao, 2018. "Meta-Prediction of MTHFR Gene Polymorphisms and Air Pollution on the Risk of Hypertensive Disorders in Pregnancy Worldwide," IJERPH, MDPI, vol. 15(2), pages 1-14, February.

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