IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0086194.html
   My bibliography  Save this article

Survival According to BRAF-V600 Tumor Mutations – An Analysis of 437 Patients with Primary Melanoma

Author

Listed:
  • Diana Meckbach
  • Jürgen Bauer
  • Annette Pflugfelder
  • Friedegund Meier
  • Christian Busch
  • Thomas K Eigentler
  • David Capper
  • Andreas von Deimling
  • Michel Mittelbronn
  • Sven Perner
  • Kristian Ikenberg
  • Markus Hantschke
  • Petra Büttner
  • Claus Garbe
  • Benjamin Weide

Abstract

The prognostic impact of BRAF-V600 tumor mutations in stage I/II melanoma patients has not yet been analyzed in detail. We investigated primary tumors of 437 patients diagnosed between 1989 and 2006 by Sanger sequencing. Mutations were detected in 38.7% of patients and were associated with age, histological subtype as well as mitotic rate. The mutational rate was 36.7% in patients with disease-free course and 51.7% in those with subsequent distant metastasis (p = 0.031). No difference in overall survival (p = 0.119) but a trend for worse distant-metastasis-free survival (p = 0.061) was observed in BRAF mutant compared to BRAF wild-type patients. Independent prognostic factors for overall survival were tumor thickness, mitotic rate and ulceration. An interesting significant prognostic impact was observed in patients with tumor thickness of 1 mm or less, with the mutation present in 6 of 7 patients dying from melanoma. In conclusion, no significant survival differences were found according to BRAF-V600 tumor mutations in patients with primary melanoma but an increasing impact of the mutational status was observed in the subgroup of patients with tumor thickness of 1 mm or less. A potential role of the mutational status as a prognostic factor especially in this subgroup needs to be investigated in larger studies.

Suggested Citation

  • Diana Meckbach & Jürgen Bauer & Annette Pflugfelder & Friedegund Meier & Christian Busch & Thomas K Eigentler & David Capper & Andreas von Deimling & Michel Mittelbronn & Sven Perner & Kristian Ikenbe, 2014. "Survival According to BRAF-V600 Tumor Mutations – An Analysis of 437 Patients with Primary Melanoma," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-10, January.
    • Handle: RePEc:plo:pone00:0086194
    DOI: 10.1371/journal.pone.0086194
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086194
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0086194&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0086194?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Helen Davies & Graham R. Bignell & Charles Cox & Philip Stephens & Sarah Edkins & Sheila Clegg & Jon Teague & Hayley Woffendin & Mathew J. Garnett & William Bottomley & Neil Davis & Ed Dicks & Rebecca, 2002. "Mutations of the BRAF gene in human cancer," Nature, Nature, vol. 417(6892), pages 949-954, June.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Chuan-Hsin Chang & Yue-Cune Chang, 2022. "Comparing the Therapeutic Efficacies of Lung Cancer: Network Meta-Analysis Approaches," IJERPH, MDPI, vol. 19(21), pages 1-20, November.
    2. Palistha Shrestha & Jeevan Kandel & Hilal Tayara & Kil To Chong, 2024. "Post-translational modification prediction via prompt-based fine-tuning of a GPT-2 model," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Josefine Radke & Elisa Schumann & Julia Onken & Randi Koll & Güliz Acker & Bohdan Bodnar & Carolin Senger & Sascha Tierling & Markus Möbs & Peter Vajkoczy & Anna Vidal & Sandra Högler & Petra Kodajova, 2022. "Decoding molecular programs in melanoma brain metastases," Nature Communications, Nature, vol. 13(1), pages 1-24, December.
    4. Hazem El-Osta & Gerald Falchook & Apostolia Tsimberidou & David Hong & Aung Naing & Kevin Kim & Sijin Wen & Filip Janku & Razelle Kurzrock, 2011. "BRAF Mutations in Advanced Cancers: Clinical Characteristics and Outcomes," PLOS ONE, Public Library of Science, vol. 6(10), pages 1-13, October.
    5. Sony Malhotra & Ali F Alsulami & Yang Heiyun & Bernardo Montano Ochoa & Harry Jubb & Simon Forbes & Tom L Blundell, 2019. "Understanding the impacts of missense mutations on structures and functions of human cancer-related genes: A preliminary computational analysis of the COSMIC Cancer Gene Census," PLOS ONE, Public Library of Science, vol. 14(7), pages 1-22, July.
    6. Marti Bernardo-Faura & Stefan Massen & Christine S Falk & Nathan R Brady & Roland Eils, 2014. "Data-Derived Modeling Characterizes Plasticity of MAPK Signaling in Melanoma," PLOS Computational Biology, Public Library of Science, vol. 10(9), pages 1-18, September.
    7. Eunyoung Park & Shaun Rawson & Anna Schmoker & Byeong-Won Kim & Sehee Oh & Kangkang Song & Hyesung Jeon & Michael J. Eck, 2023. "Cryo-EM structure of a RAS/RAF recruitment complex," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    8. Jasmeen Oberoi & Xavi Aran Guiu & Emily A. Outwin & Pascale Schellenberger & Theodoros I. Roumeliotis & Jyoti S. Choudhary & Laurence H. Pearl, 2022. "HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0086194. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.