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Tumor Necrosis Factor-A Polymorphisms and Colorectal Cancer Risk: A Meta-Analysis

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  • Li Min
  • Duo Chen
  • Like Qu
  • Chengchao Shou

Abstract

Background and Objectives: Tumor necrosis factor-alpha (TNF-a) was related to inflammation and involved in the development of colorectal cancer. Polymorphisms located in TNF-a promoter region, such as 308G/A and 238G/A, could affect the risk of various types of cancer by regulating TNF-a production. In this study, a meta-analysis was performed to investigate the association between common polymorphisms of TNF-a promoter region and colorectal cancer susceptibility. Methods: Searching of several databases was performed for all publications on the association between TNF-a polymorphisms and colorectal cancer. Summary odds ratios (ORs) with their 95% confidence intervals (95% CIs) were calculated using random-effects models. Stratified analyses based on ethnicity and control population source were also conducted. Results: Overall, TNF-a 308A polymorphism showed a significant association with increased risk of colorectal cancer in worldwide populations under homozygote comparison [AA vs. GG, OR (95% CI) = 1.46 (1.07–1.97)] other than heterozygote comparison [AG vs. GG, OR (95% CI) = 1.05 (0.93–1.19)]. TNF-a 238A was not associated with colorectal cancer risk under homozygote or heterozygote comparisons. In stratified analysis, significant association was observed only in Western populations [AA vs. GG, OR (95% CI) = 1.39 (1.01–1.91)] other than in Eastern populations under homozygote comparison. No significant difference was observed between population-based subgroup and hospital-based subgroup. Conclusions: TNF-a 308A was moderately associated with an increased risk of colorectal cancer in Western populations, and TNF-a 238A polymorphism was not significantly associated with colorectal cancer risk.

Suggested Citation

  • Li Min & Duo Chen & Like Qu & Chengchao Shou, 2014. "Tumor Necrosis Factor-A Polymorphisms and Colorectal Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-7, January.
    • Handle: RePEc:plo:pone00:0085187
    DOI: 10.1371/journal.pone.0085187
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    References listed on IDEAS

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    1. Yan Hong & Zhijun Ge & Changrui Jing & Jun Shi & Xiao Dong & Fengying Zhou & Meilin Wang & Zhengdong Zhang & Weida Gong, 2013. "Functional Promoter -308G>A Variant in Tumor Necrosis Factor α Gene Is Associated with Risk and Progression of Gastric Cancer in a Chinese Population," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-6, January.
    2. Ping Zhou & Guo-Qiang Lv & Jian-Zhong Wang & Cheng-Wan Li & Liang-Feng Du & Chun Zhang & Jian-Ping Li, 2011. "The TNF-Alpha-238 Polymorphism and Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 6(7), pages 1-5, July.
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    1. Cho Naing & Norah Htet Htet & Wong Siew Tung & Arun Kumar Basavaraj & Joon Wah Mak, 2018. "Association of tumour necrosis factor-α (TNF-α) gene polymorphisms (-308 G>A and -238 G>A) and the risk of severe dengue: A meta-analysis and trial sequential analysis," PLOS ONE, Public Library of Science, vol. 13(10), pages 1-12, October.

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