IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0022092.html
   My bibliography  Save this article

The TNF-Alpha-238 Polymorphism and Cancer Risk: A Meta-Analysis

Author

Listed:
  • Ping Zhou
  • Guo-Qiang Lv
  • Jian-Zhong Wang
  • Cheng-Wan Li
  • Liang-Feng Du
  • Chun Zhang
  • Jian-Ping Li

Abstract

Background and Objectives: Tumor necrosis factor-α (TNF-α) plays a very important role in the development and progress of cancer. Some TNF-α polymorphisms have been confirmed to increase cancer risks; however, the association between TNF-α-238 polymorphism and cancers remains controversial and ambiguous. The aim of this study is to explore a more precise estimation of its relationship with cancer using meta-analysis. Methods: Electronic searches of several databases were conducted for all publications on the association between this variant and cancer through March 2011. Odds ratios (OR) with 95% confidence intervals (95% CI) were used to access the strength of this association in the random-effect model. Results: Thirty four studies with 34,679 cancer patients and 41,186 healthy controls were included. This meta-analysis showed no significant association between TNF-α-238 polymorphism and cancers (AA+GA vs GG: OR = 1.09, 95%CI = 0.88–1.34). In Caucasian and Asian subgroups, OR values (95% CI) were 1.14 (0.91–1.43) and 0.97 (0.58–1.61), respectively. In the subgroups of cancer type, no significant association was detected. The sensitivity analysis further strengthened the validity of these negative associations. No publication bias was observed in this study. Conclusions: No significant association was found between the TNF-α-238 polymorphism and the risk for cancer.

Suggested Citation

  • Ping Zhou & Guo-Qiang Lv & Jian-Zhong Wang & Cheng-Wan Li & Liang-Feng Du & Chun Zhang & Jian-Ping Li, 2011. "The TNF-Alpha-238 Polymorphism and Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 6(7), pages 1-5, July.
  • Handle: RePEc:plo:pone00:0022092
    DOI: 10.1371/journal.pone.0022092
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022092
    Download Restriction: no

    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0022092&type=printable
    Download Restriction: no

    File URL: https://libkey.io/10.1371/journal.pone.0022092?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Li Min & Duo Chen & Like Qu & Chengchao Shou, 2014. "Tumor Necrosis Factor-A Polymorphisms and Colorectal Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-7, January.
    2. Bei-Bei Zhang & Xing-Zhen Liu & Jin Sun & Yan-Wei Yin & Qian-Qian Sun, 2013. "Association between TNF α Gene Polymorphisms and the Risk of Duodenal Ulcer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-7, February.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0022092. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.