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HLA-DQB1*03 Confers Susceptibility to Chronic Hepatitis C in Japanese: A Genome-Wide Association Study

Author

Listed:
  • Daiki Miki
  • Hidenori Ochi
  • Atsushi Takahashi
  • C Nelson Hayes
  • Yuji Urabe
  • Hiromi Abe
  • Tomokazu Kawaoka
  • Masataka Tsuge
  • Nobuhiko Hiraga
  • Michio Imamura
  • Yoshiiku Kawakami
  • Hiroshi Aikata
  • Shoichi Takahashi
  • Norio Akuta
  • Fumitaka Suzuki
  • Kenji Ikeda
  • Hiromitsu Kumada
  • Yoshiyasu Karino
  • Joji Toyota
  • Tatsuhiko Tsunoda
  • Michiaki Kubo
  • Naoyuki Kamatani
  • Yusuke Nakamura
  • Kazuaki Chayama

Abstract

Hepatitis C virus (HCV) establishes a chronic infection in 70-80% of infected individuals. Many researchers have examined the effect of human leukocyte antigen (HLA) on viral persistence because of its critical role in the immune response against exposure to HCV, but almost all studies have proven to be inconclusive. To identify genetic risk factors for chronic HCV infection, we analyzed 458,207 single nucleotide polymorphisms (SNPs) in 481 chronic HCV patients and 2,963 controls in a Japanese cohort. Next, we performed a replication study with an independent panel of 4,358 cases and 1,114 controls. We further confirmed the association in 1,379 cases and 25,817 controls. In the GWAS phase, we found 17 SNPs that showed suggestive association (P

Suggested Citation

  • Daiki Miki & Hidenori Ochi & Atsushi Takahashi & C Nelson Hayes & Yuji Urabe & Hiromi Abe & Tomokazu Kawaoka & Masataka Tsuge & Nobuhiko Hiraga & Michio Imamura & Yoshiiku Kawakami & Hiroshi Aikata & , 2013. "HLA-DQB1*03 Confers Susceptibility to Chronic Hepatitis C in Japanese: A Genome-Wide Association Study," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-1, December.
    • Handle: RePEc:plo:pone00:0084226
    DOI: 10.1371/journal.pone.0084226
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    References listed on IDEAS

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    1. David L. Thomas & Chloe L. Thio & Maureen P. Martin & Ying Qi & Dongliang Ge & Colm O’hUigin & Judith Kidd & Kenneth Kidd & Salim I. Khakoo & Graeme Alexander & James J. Goedert & Gregory D. Kirk & Sh, 2009. "Genetic variation in IL28B and spontaneous clearance of hepatitis C virus," Nature, Nature, vol. 461(7265), pages 798-801, October.
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