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Genetic variation in IL28B and spontaneous clearance of hepatitis C virus

Author

Listed:
  • David L. Thomas

    (Johns Hopkins University, Baltimore, Maryland 21205, USA)

  • Chloe L. Thio

    (Johns Hopkins University, Baltimore, Maryland 21205, USA)

  • Maureen P. Martin

    (Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA, and Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, Massachusetts 02114, USA)

  • Ying Qi

    (Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA, and Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, Massachusetts 02114, USA)

  • Dongliang Ge

    (Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA)

  • Colm O’hUigin

    (Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA, and Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, Massachusetts 02114, USA)

  • Judith Kidd

    (Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA)

  • Kenneth Kidd

    (Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA)

  • Salim I. Khakoo

    (Imperial College)

  • Graeme Alexander

    (University of Cambridge)

  • James J. Goedert

    (Infections & Immunoepidemiology Branch, National Cancer Institute, Rockville, Maryland 20852, USA)

  • Gregory D. Kirk

    (Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA)

  • Sharyne M. Donfield

    (Rho, Inc., Chapel Hill, North Carolina 27517, USA)

  • Hugo R. Rosen

    (University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA)

  • Leslie H. Tobler

    (Blood Systems Research Institute, San Francisco, California 94118, USA)

  • Michael P. Busch

    (Blood Systems Research Institute, San Francisco, California 94118, USA)

  • John G. McHutchison

    (School of Medicine, Duke University, Durham, North Carolina 27705, USA)

  • David B. Goldstein

    (Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA)

  • Mary Carrington

    (Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA, and Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, Massachusetts 02114, USA
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, Massachusetts 02114, USA)

Abstract

IL28B and hepatitis C Hepatitis C virus (HCV) infection is the most common blood-borne infection in the United States, leading in many cases to chronic liver disease. Here the authors show that an SNP recently identified to associate with response to HCV drug treatment also associates with viral clearance. This study identifies the strongest and most significant genetic effect associated with natural clearance of HCV, implicating a primary role for IL28B in this process.

Suggested Citation

  • David L. Thomas & Chloe L. Thio & Maureen P. Martin & Ying Qi & Dongliang Ge & Colm O’hUigin & Judith Kidd & Kenneth Kidd & Salim I. Khakoo & Graeme Alexander & James J. Goedert & Gregory D. Kirk & Sh, 2009. "Genetic variation in IL28B and spontaneous clearance of hepatitis C virus," Nature, Nature, vol. 461(7265), pages 798-801, October.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7265:d:10.1038_nature08463
    DOI: 10.1038/nature08463
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    Citations

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    Cited by:

    1. Francesc Vidal & Miguel López-Dupla & Montserrat Laguno & Sergi Veloso & Josep Mallolas & Javier Murillas & Carmen Cifuentes & Lluis Gallart & Teresa Auguet & Gloria Sampériz & Antoni Payeras & Pilar , 2012. "Pharmacogenetics of Efficacy and Safety of HCV Treatment in HCV-HIV Coinfected Patients: Significant Associations with IL28B and SOCS3 Gene Variants," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-9, November.
    2. Daiki Miki & Hidenori Ochi & Atsushi Takahashi & C Nelson Hayes & Yuji Urabe & Hiromi Abe & Tomokazu Kawaoka & Masataka Tsuge & Nobuhiko Hiraga & Michio Imamura & Yoshiiku Kawakami & Hiroshi Aikata & , 2013. "HLA-DQB1*03 Confers Susceptibility to Chronic Hepatitis C in Japanese: A Genome-Wide Association Study," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-1, December.
    3. William S. Grubbe & Bixia Zhang & Aileen Kauffman & Fabian Byléhn & Kasia Padoł & Hae-Gwang Jung & Seung Bum Park & Jessica M. Priest & Engin Özkan & Juan J. de Pablo & T. Jake Liang & Minglei Zhao & , 2025. "Structural studies of the IFNλ4 receptor complex using cryoEM enabled by protein engineering," Nature Communications, Nature, vol. 16(1), pages 1-12, December.
    4. Xiaoyan Guo & Guilin Yang & Jin Yuan & Peng Ruan & Mingxia Zhang & Xincun Chen & Boping Zhou, 2013. "Genetic Variation in Interleukin 28B and Response to Antiviral Therapy in Patients with Dual Chronic Infection with Hepatitis B and C Viruses," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-1, October.
    5. Ja-Young Han & Jae-Hee Kwon & Sun-Hwa Kim & Heeyoung Lee, 2023. "Hepatitis Risk in Diabetes Compared to Non-Diabetes and Relevant Factors: A Cross-Sectional Study with National Health and Nutrition Examination Survey (NHANES), 2013–2018," IJERPH, MDPI, vol. 20(6), pages 1-12, March.
    6. Felix M Key & Benjamin Peter & Megan Y Dennis & Emilia Huerta-Sánchez & Wei Tang & Ludmila Prokunina-Olsson & Rasmus Nielsen & Aida M Andrés, 2014. "Selection on a Variant Associated with Improved Viral Clearance Drives Local, Adaptive Pseudogenization of Interferon Lambda 4 (IFNL4)," PLOS Genetics, Public Library of Science, vol. 10(10), pages 1-12, October.
    7. Deanna M. Santer & Daniel Li & Yanal Ghosheh & Muhammad Atif Zahoor & Dhanvi Prajapati & Bettina E. Hansen & D. Lorne J. Tyrrell & Jordan J. Feld & Adam J. Gehring, 2022. "Interferon-λ treatment accelerates SARS-CoV-2 clearance despite age-related delays in the induction of T cell immunity," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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