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For or against Adjuvant Trastuzumab for pT1a-bN0M0 Breast Cancer Patients with HER2-Positive Tumors: A Meta-Analysis of Published Literatures

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  • Qiong Zhou
  • Wenjin Yin
  • Yueyao Du
  • Jinsong Lu

Abstract

Background: Although the prognosis of patients with small (≤1cm) tumors is generally favorable, emerging data suggests that biological behavior varies between intrinsic subtypes in such patients. Furthermore, it still remains unclear whether HER2-positive pT1a-bN0M0 patients could benefit from adjuvant trastuzumab. For further evaluation, we sought to conduct a meta-analysis so as to get a better understanding of the prognosis for HER2-positive pT1a-bN0M0 patients and their survival benefit from adjuvant trastuzumab, accordingly, offering the implications for current practice. Methods: The PubMed database, the online proceedings of the American Society of Clinical Oncology (ASCO) Annual Meetings, the online proceedings of the San Antonio Breast Cancer Symposium, and the CD proceedings of the International St. Gallen Breast Cancer Conference were searched for all relevant studies published before September 2012. Relative risks (RRs) were used to compare the prognosis of different intrinsic subtypes for pT1a-bN0M0 breast cancer. Analyses were also performed to estimate the association between adjuvant trastuzumab and various survival outcomes. Results: With eight eligible studies identified, this meta-analysis demonstrated a deleterious effect of HER2+ phenotype on disease-free survival (DFS; RR = 3.677, 95% CI 2.606–5.189, p

Suggested Citation

  • Qiong Zhou & Wenjin Yin & Yueyao Du & Jinsong Lu, 2014. "For or against Adjuvant Trastuzumab for pT1a-bN0M0 Breast Cancer Patients with HER2-Positive Tumors: A Meta-Analysis of Published Literatures," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-7, January.
  • Handle: RePEc:plo:pone00:0083646
    DOI: 10.1371/journal.pone.0083646
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    References listed on IDEAS

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    1. Wenjin Yin & Yiwei Jiang & Zhenzhou Shen & Zhimin Shao & Jinsong Lu, 2011. "Trastuzumab in the Adjuvant Treatment of HER2-Positive Early Breast Cancer Patients: A Meta-Analysis of Published Randomized Controlled Trials," PLOS ONE, Public Library of Science, vol. 6(6), pages 1-9, June.
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    Cited by:

    1. Stefania Gori & Alessandro Inno & Elena Fiorio & Jennifer Foglietta & Antonella Ferro & Marcella Gulisano & Graziella Pinotti & Marta Gubiotti & Maria Giovanna Cavazzini & Monica Turazza & Simona Dura, 2015. "The Promher Study: An Observational Italian Study on Adjuvant Therapy for HER2-Positive, pT1a-b pN0 Breast Cancer," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-14, September.

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