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Trastuzumab in the Adjuvant Treatment of HER2-Positive Early Breast Cancer Patients: A Meta-Analysis of Published Randomized Controlled Trials

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  • Wenjin Yin
  • Yiwei Jiang
  • Zhenzhou Shen
  • Zhimin Shao
  • Jinsong Lu

Abstract

Background: Adjuvant trastuzumab therapy has yielded conflicting results for overall survival, concerns about central nervous system (CNS) metastasis, and questions about optimal schedule. Therefore, we carried out a meta-analysis to assess the benefits of concurrent or sequential trastuzumab with adjuvant chemotherapy for early breast cancer patients with HER2-positive tumors. Methods: Computerized and manual searches were performed to identify randomized clinical trials comparing adjuvant chemotherapy with or without trastuzumab in HER2-positive early breast cancer patients. Odds ratios were used to estimate the association between the addition of trastuzumab to adjuvant chemotherapy and various survival outcomes. The fixed-effects or random-effects model was used to combine data. Findings: With six eligible studies identified, this analysis demonstrated that patients with HER2-positive breast cancer derived benefit in disease-free survival, overall survival, locoregional recurrence and distant recurrence (all P

Suggested Citation

  • Wenjin Yin & Yiwei Jiang & Zhenzhou Shen & Zhimin Shao & Jinsong Lu, 2011. "Trastuzumab in the Adjuvant Treatment of HER2-Positive Early Breast Cancer Patients: A Meta-Analysis of Published Randomized Controlled Trials," PLOS ONE, Public Library of Science, vol. 6(6), pages 1-9, June.
    • Handle: RePEc:plo:pone00:0021030
    DOI: 10.1371/journal.pone.0021030
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    Cited by:

    1. Jeroen J. van den Broek & Nicolien T. van Ravesteyn & Eveline A. Heijnsdijk & Harry J. de Koning, 2018. "Simulating the Impact of Risk-Based Screening and Treatment on Breast Cancer Outcomes with MISCAN-Fadia," Medical Decision Making, , vol. 38(1_suppl), pages 54-65, April.
    2. Caroline S Clarke & Rachael M Hunter & Ian Shemilt & Victoria Serra-Sastre, 2017. "Multi-arm Cost-Effectiveness Analysis (CEA) comparing different durations of adjuvant trastuzumab in early breast cancer, from the English NHS payer perspective," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-19, March.
    3. Qiong Zhou & Wenjin Yin & Yueyao Du & Jinsong Lu, 2014. "For or against Adjuvant Trastuzumab for pT1a-bN0M0 Breast Cancer Patients with HER2-Positive Tumors: A Meta-Analysis of Published Literatures," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-7, January.

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