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Translational Science by Public Biotechnology Companies in the IPO“Class of 2000”: The Impact of Technological Maturity

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  • Laura McNamee
  • Fred Ledley

Abstract

The biotechnology industry plays a central role in the translation of nascent biomedical science into both products that offer material health benefits and creating capital growth. This study examines the relationship between the maturity of technologies in a characteristic life cycle and value creation by biotechnology companies. We examined the core technology, product development pipelines, and capitalization for a cohort of biotechnology companies that completed an IPO in 2000. Each of these companies was well financed and had core technologies on the leading edge of biological science. We found that companies with the least mature technologies had significantly higher valuations at IPO, but failed to develop products based on these technologies over the ensuing decade, and created less capital growth than companies with more mature technologies at IPO. The observation that this cohort of recently public biotechnology companies was not effective in creating value from nascent science suggests the need for new, evidence-based business strategies for translational science.

Suggested Citation

  • Laura McNamee & Fred Ledley, 2013. "Translational Science by Public Biotechnology Companies in the IPO“Class of 2000”: The Impact of Technological Maturity," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-7, December.
    • Handle: RePEc:plo:pone00:0082195
    DOI: 10.1371/journal.pone.0082195
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    1. Morris, Michael & Schindehutte, Minet & Allen, Jeffrey, 2005. "The entrepreneur's business model: toward a unified perspective," Journal of Business Research, Elsevier, vol. 58(6), pages 726-735, June.
    2. Henry Chesbrough & Richard S. Rosenbloom, 2002. "The role of the business model in capturing value from innovation: evidence from Xerox Corporation's technology spin-off companies," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 11(3), pages 529-555, June.
    3. Ilan Guedj & David Scharfstein, 2004. "Organizational Scope and Investment: Evidence from the Drug Development Strategies and Performance of Biopharmaceutical Firms," NBER Working Papers 10933, National Bureau of Economic Research, Inc.
    4. Iain M. Cockburn & Rebecca M. Henderson, 1998. "Absorptive Capacity, Coauthoring Behavior, and the Organization of Research in Drug Discovery," Journal of Industrial Economics, Wiley Blackwell, vol. 46(2), pages 157-182, June.
    5. Heidi Ledford, 2013. "Biotech boom prompts fears of bust," Nature, Nature, vol. 500(7464), pages 513-513, August.
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    Cited by:

    1. Chandra, Praveena & Dong, Andy, 2018. "The relation between knowledge accumulation and technical value in interdisciplinary technologies," Technological Forecasting and Social Change, Elsevier, vol. 128(C), pages 235-244.

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