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Functional IL-23R rs10889677 Genetic Polymorphism and Risk of Multiple Solid Tumors: a Meta-Analysis

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  • Shanliang Zhou
  • Yueqin Ruan
  • Hongchen Yu
  • Yunzhi Chen
  • Yongjun Yao
  • Yanhui Ma
  • Yan Gao

Abstract

Interleukin-23 receptor (IL23R) can interact with IL-23 and, thus, is involved in the T-helper 17 (Th17) cell-mediated inflammatory process as well as tumorigenesis. Recently, a functional single nucleotide polymorphism (SNP) rs10889677 has been identified in the 3’-untranslated region of IL-23R. It has been showed that the rs10889677AC SNP could increase the binding affinity of microRNA let-7f and downregulate IL-23R expression. Several case-control studies have examined the association between this SNP and genetic susceptibility of multiple solid tumors. However, the conclusions are conflicting. Therefore, we conducted this meta-analysis to systematically study the role of this functional IL-23R SNP in development of multiple solid tumors. There are a total of 5 studies are eligible (6731 cases and 7296 healthy controls). Either fixed-effect model or random-effect model was used to calculate pooled odds ratios (ORs) and the 95% confidence interval (95% CI). Significant association between this functional rs10889677 genetic variant and risk of multiple solid tumors were observed (CC genotype vs. AA genotype: OR = 0.59, 95% CI = 0.53-0.66, P

Suggested Citation

  • Shanliang Zhou & Yueqin Ruan & Hongchen Yu & Yunzhi Chen & Yongjun Yao & Yanhui Ma & Yan Gao, 2013. "Functional IL-23R rs10889677 Genetic Polymorphism and Risk of Multiple Solid Tumors: a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-1, November.
    • Handle: RePEc:plo:pone00:0080627
    DOI: 10.1371/journal.pone.0080627
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    1. John L. Langowski & Xueqing Zhang & Lingling Wu & Jeanine D. Mattson & Taiying Chen & Kathy Smith & Beth Basham & Terrill McClanahan & Robert A. Kastelein & Martin Oft, 2006. "IL-23 promotes tumour incidence and growth," Nature, Nature, vol. 442(7101), pages 461-465, July.
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