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IL-23 promotes tumour incidence and growth

Author

Listed:
  • John L. Langowski

    (Schering-Plough BioPharma (formerly DNAX Research, Inc.))

  • Xueqing Zhang

    (Schering-Plough BioPharma (formerly DNAX Research, Inc.))

  • Lingling Wu

    (Schering-Plough BioPharma (formerly DNAX Research, Inc.))

  • Jeanine D. Mattson

    (Schering-Plough BioPharma (formerly DNAX Research, Inc.))

  • Taiying Chen

    (Schering-Plough BioPharma (formerly DNAX Research, Inc.))

  • Kathy Smith

    (Schering-Plough BioPharma (formerly DNAX Research, Inc.))

  • Beth Basham

    (Schering-Plough BioPharma (formerly DNAX Research, Inc.))

  • Terrill McClanahan

    (Schering-Plough BioPharma (formerly DNAX Research, Inc.))

  • Robert A. Kastelein

    (Schering-Plough BioPharma (formerly DNAX Research, Inc.))

  • Martin Oft

    (Schering-Plough BioPharma (formerly DNAX Research, Inc.))

Abstract

Missing link A long-sought link between cancer and inflammation has been found. Inflammation triggered by interleukin-23(IL-23), which is present in many human tumours, seems to help tumours grow by protecting them from the immune system and by promoting blood vessel formation. Mice born without IL-23 are protected against cancer, as are mice in which IL-23 is blocked by antibodies, suggesting that a similar strategy might be possible against human cancers.

Suggested Citation

  • John L. Langowski & Xueqing Zhang & Lingling Wu & Jeanine D. Mattson & Taiying Chen & Kathy Smith & Beth Basham & Terrill McClanahan & Robert A. Kastelein & Martin Oft, 2006. "IL-23 promotes tumour incidence and growth," Nature, Nature, vol. 442(7101), pages 461-465, July.
    • Handle: RePEc:nat:nature:v:442:y:2006:i:7101:d:10.1038_nature04808
    DOI: 10.1038/nature04808
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    Cited by:

    1. Shanliang Zhou & Yueqin Ruan & Hongchen Yu & Yunzhi Chen & Yongjun Yao & Yanhui Ma & Yan Gao, 2013. "Functional IL-23R rs10889677 Genetic Polymorphism and Risk of Multiple Solid Tumors: a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-1, November.
    2. Jonathan W. Lo & Domenico Cozzetto & James L. Alexander & Nathan P. Danckert & Matthew Madgwick & Naomi Knox & Jillian Yong Xin Sieh & Marton Olbei & Zhigang Liu & Hajir Ibraheim & Jesus Miguens Blanc, 2023. "Immune checkpoint inhibitor-induced colitis is mediated by polyfunctional lymphocytes and is dependent on an IL23/IFNγ axis," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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