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A Functional Variant rs1820453 in YAP1 and Breast Cancer Risk in Chinese Population

Author

Listed:
  • Wei Chen
  • Wei Wang
  • Beibei Zhu
  • Hui Guo
  • Yu Sun
  • Jie Ming
  • Na Shen
  • Zhi Li
  • Zhenling Wang
  • Lifeng Liu
  • Bingxi Cai
  • Jiayu Duan
  • Jiaoyuan Li
  • Cheng Liu
  • Rong Zhong
  • Weiguo Hu
  • Tao Huang
  • Xiaoping Miao

Abstract

Background: To investigate the association between rs1820453 which located in the promoter region of yes-associated protein 1 (YAP1) gene and breast cancer (BC) risk. Method and Findings: We conducted a hospital-based case-control study including a total of 480 BC cases and 545 cancer-free controls in Chinese population. Then the expression quantitative trait locus (e-QTL) analysis was performed to explore the possible function of rs1820453 to the YAP1 gene expression. The association between rs1820453 and BC risk was significantly identified with the odds ratio (OR) was 1.27 (95 % confidence interval (CI) =1.03-1.57) under allelic model when adjusted by age and menopausal status. In addition, the correlation analysis of rs1820453 and YAP1 expression level found that this variant was significantly associated with the gene expression in Chinese population. When compared with level of mRNA expression of the AA genotype (6.011±0.046), the mRNA expression level in CC genotype (5.903±0.026) was statistically lower (P=0.024). Conclusion: The results from this study suggested that rs1820453 A>C change may affect the gene expression and contribute to the risk of developing BC in Chinese population though larger sample-size studies along with functional experiments were anticipated to warrant the results.

Suggested Citation

  • Wei Chen & Wei Wang & Beibei Zhu & Hui Guo & Yu Sun & Jie Ming & Na Shen & Zhi Li & Zhenling Wang & Lifeng Liu & Bingxi Cai & Jiayu Duan & Jiaoyuan Li & Cheng Liu & Rong Zhong & Weiguo Hu & Tao Huang , 2013. "A Functional Variant rs1820453 in YAP1 and Breast Cancer Risk in Chinese Population," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-1, November.
    • Handle: RePEc:plo:pone00:0079056
    DOI: 10.1371/journal.pone.0079056
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    References listed on IDEAS

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    1. Douglas F. Easton & Karen A. Pooley & Alison M. Dunning & Paul D. P. Pharoah & Deborah Thompson & Dennis G. Ballinger & Jeffery P. Struewing & Jonathan Morrison & Helen Field & Robert Luben & Nicholas, 2007. "Genome-wide association study identifies novel breast cancer susceptibility loci," Nature, Nature, vol. 447(7148), pages 1087-1093, June.
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