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Relationship of the p22phox (CYBA) Gene Polymorphism C242T with Risk of Coronary Artery Disease: A Meta-Analysis

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  • Zhijun Wu
  • Yuqing Lou
  • Wei Jin
  • Yan Liu
  • Lin Lu
  • Qiujing Chen
  • Yucai Xie
  • Guoping Lu

Abstract

Background: Observational and experimental studies have thus far been unable to resolve whether the CYBA C242T polymorphism is associated with coronary artery disease (CAD). Therefore, we undertook a comprehensive meta-analysis to more precisely evaluate the influence of this polymorphism on CAD and potential biases. Methods: We screened MEDLINE, Embase, CNKI, Wanfang and CBM up to January 2013 and extracted data from 22 studies with 9,279 CAD patients and 9,349 controls. A random-effects model was exploited to synthesize the inconsistent outcomes of the individual studies, while addressing between-study heterogeneity and publication bias. Results: The CYBA C242T polymorphism conformed to Hard-Weinberg Equilibrium for all studies (P>0.05). Overall comparison of the T allele with the C allele produced a non-significant risk estimate for CAD but with striking heterogeneity (T versus C: P = 0.87, OR = 0.99, 95%CI 0.89–1.11, Pheterogeneity

Suggested Citation

  • Zhijun Wu & Yuqing Lou & Wei Jin & Yan Liu & Lin Lu & Qiujing Chen & Yucai Xie & Guoping Lu, 2013. "Relationship of the p22phox (CYBA) Gene Polymorphism C242T with Risk of Coronary Artery Disease: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-14, September.
    • Handle: RePEc:plo:pone00:0070885
    DOI: 10.1371/journal.pone.0070885
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    Cited by:

    1. Kuo-Jung Ho & Tzu-Hua Chen & Chen-Cheng Yang & Yao-Chung Chuang & Hung-Yi Chuang, 2021. "Interaction of Smoking and Lead Exposure among Carriers of Genetic Variants Associated with a Higher Level of Oxidative Stress Indicators," IJERPH, MDPI, vol. 18(16), pages 1-12, August.
    2. Zhijun Wu & Huan Zhang & Wei Jin & Yan Liu & Lin Lu & Qiujing Chen & Ruiyan Zhang, 2015. "The Effect of Renin-Angiotensin-Aldosterone System Blockade Medications on Contrast-Induced Nephropathy in Patients Undergoing Coronary Angiography: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-18, June.
    3. Zhijun Wu & Yuqing Lou & Lin Lu & Yan Liu & Qiujing Chen & Xin Chen & Wei Jin, 2014. "Heterogeneous Effect of Two Selectin Gene Polymorphisms on Coronary Artery Disease Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-12, February.

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