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Interaction of Smoking and Lead Exposure among Carriers of Genetic Variants Associated with a Higher Level of Oxidative Stress Indicators

Author

Listed:
  • Kuo-Jung Ho

    (Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung City 807, Taiwan)

  • Tzu-Hua Chen

    (Department of Family Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung City 807, Taiwan)

  • Chen-Cheng Yang

    (Department of Occupational and Environmental Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung City 807, Taiwan)

  • Yao-Chung Chuang

    (Institute for Translation Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City 833, Taiwan)

  • Hung-Yi Chuang

    (Department of Occupational and Environmental Medicine, Kaohsiung Medical University Hospital, Kaohsiung City 807, Taiwan
    Department of Public Health and Environmental Medicine, College of Medicine, Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung City 807, Taiwan)

Abstract

Smoking and lead (Pb) exposure increased oxidative stress in human body, and people with some gene variants may be susceptible to Pb and smoking via oxidative stress. The aim of this study is to evaluate oxidative stress by measuring thiobarbituric acid reactive substances (TBARS) and the relationship of lipid peroxidation markers in Pb workers with different gene polymorphisms (rs4673 and rs1050450) in both smokers and nonsmokers. Blood samples were collected from 267 Pb workers who received their annual health examination in the Kaohsiung Medical University Hospital. Glutathione peroxidase 1 (GPx-1) rs1050450 and cytochrome B-245 Alpha Chain (CYBA) rs4673 single-nucleotide polymorphisms (SNP) were analyzed by specific primer-probes using Real-Time PCR methods. The interaction between blood Pb and smoking increased serum levels of TBARS and the ratio of oxidative low-density lipoprotein and low-density lipoprotein (oxLDL/LDL). Analysis of workers with rs1050450 SNPs showed higher blood Pb levels in the workers with CC genotype than those with CT genotype. Smokers had significantly higher blood Pb, alanine transaminase (ALT), TBARS, and OxLDL levels than nonsmokers. TBARS increased 0.009 nmol/mL when blood Pb increased one µg/dL in smokers compared to nonsmokers. The ratio of OxLDL/LDL increased 0.223 when blood Pb increased one µg/dL in smokers compared to nonsmokers. TBARS levels and the ratio of OxLDL/LDL were positively correlated and interacted between blood Pb and smoking after the adjustment of confounders, suggesting that smoking cessation is an important issue in the Pb-exposed working environment.

Suggested Citation

  • Kuo-Jung Ho & Tzu-Hua Chen & Chen-Cheng Yang & Yao-Chung Chuang & Hung-Yi Chuang, 2021. "Interaction of Smoking and Lead Exposure among Carriers of Genetic Variants Associated with a Higher Level of Oxidative Stress Indicators," IJERPH, MDPI, vol. 18(16), pages 1-12, August.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:16:p:8325-:d:609512
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    References listed on IDEAS

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    1. Zhijun Wu & Yuqing Lou & Wei Jin & Yan Liu & Lin Lu & Qiujing Chen & Yucai Xie & Guoping Lu, 2013. "Relationship of the p22phox (CYBA) Gene Polymorphism C242T with Risk of Coronary Artery Disease: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-14, September.
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